Research Animals Department, Royal Society for the Prevention of Cruelty to Animals, Wilberforce Way, Southwater, Horsham, West Sussex RH13 9RS, UK.
Biological Sciences, University of Southampton, 3059, Life Sciences Bldg 85, Highfield Campus, Southampton SO17 1BJ, UK.
Exp Neurol. 2020 Jun;328:113273. doi: 10.1016/j.expneurol.2020.113273. Epub 2020 Mar 3.
This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an emphasis on refinement. Specific animal welfare issues were identified and discussed, and practical measures proposed, with the aim of reducing animal use and suffering, reducing experimental variability, and increasing translatability within this critically important research field.
本报告由一个专家工作组（EWG）编写，该工作组由英国的研究人员、兽医和动物实验监管人员组成，他们在脊髓损伤（SCI）动物模型的使用方面具有专业知识。其目的是促进三 R（替代、减少和优化）的实施，重点是优化。本报告确定并讨论了具体的动物福利问题，并提出了切实可行的措施，旨在减少动物的使用和痛苦，减少实验变异性，并提高这一极其重要的研究领域的可转化性。
