通过碱辅助一锅偶联和环化过程构建 -取代的雷琐辛腙的简洁方法。
A Concise Approach to -Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process.
机构信息
Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
State Key Laboratory of Molecular Engineering and Institutes of Biomedical Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China.
出版信息
Molecules. 2020 Mar 4;25(5):1138. doi: 10.3390/molecules25051138.
An efficient approach to obtain functionalized rhodanines was developed through a base-assisted one-pot coupling and continuous cyclization of a primary amine, carbon disulfide, and methyl (2-chloroacetyl)carbamate. This conversion tolerates a broad range of functional groups and can be used to scale the preparation of -substituted rhodanines in excellent yields.
通过伯胺、二硫化碳和甲基（2-氯乙酰基）氨基甲酸酯的碱辅助一锅偶联和连续环化反应，开发出一种获得功能化罗丹宁的有效方法。这种转化可以容忍广泛的官能团，并可用于在优异产率下大规模制备 -取代的罗丹宁。
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