Department of Leisure Industry and Health Promotion, National Taipei University of Nursing and Health Sciences, Taipei City 11219, Taiwan.
Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei City 11031, Taiwan.
Int J Environ Res Public Health. 2020 Mar 4;17(5):1669. doi: 10.3390/ijerph17051669.
Physical activity has long been associated with chronic diseases. However, the association between physical activity and renal progression in hypertensive patients remains unclear. This study investigated the relationship between the level of physical activity and renal function in hypertensive patients. We analyzed 3543 patients with hypertension. Data on patients' demographic characteristics, comorbidities, physical activity, and lifestyle characteristics were collected via questionnaires. An estimated glomerular filtration rate (eGFR) that was reduced by more than 25% from the baseline eGFR was defined as renal progression. This study divided physical activity into three levels (low, moderate, and high) based on their metabolic equivalent of tasks (METs) levels. The mean age was 63.32 ± 12.29 years. After we adjusted for covariates, renal progression was significantly higher among patients with low levels of physical activity (odds ratio (OR), 1.39; 95% confidence interval (CI), 1.01-1.90)) and moderate levels of physical activity (OR, 1.39; 95% CI, 1.04-1.86) than among patients with high levels of physical activity. We found a significant association between physical activity and renal progression in hypertensive patients, especially in elderly patients and men. Therefore, to reduce the risk of renal progression, we recommend that clinicians should encourage patients to improve their physical activity.
身体活动长期以来一直与慢性病有关。然而，身体活动与高血压患者的肾脏进展之间的关系仍不清楚。本研究调查了高血压患者身体活动水平与肾功能之间的关系。我们分析了 3543 名高血压患者。通过问卷收集了患者的人口统计学特征、合并症、身体活动和生活方式特征的数据。将肾小球滤过率（eGFR）比基线 eGFR 降低超过 25%定义为肾脏进展。本研究根据其代谢当量（MET）水平将身体活动分为三个水平（低、中、高）。平均年龄为 63.32±12.29 岁。在调整了协变量后，与高身体活动水平的患者相比，低身体活动水平（比值比（OR），1.39；95%置信区间（CI），1.01-1.90）和中身体活动水平（OR，1.39；95%CI，1.04-1.86）的患者发生肾脏进展的风险明显更高。我们发现身体活动与高血压患者的肾脏进展之间存在显著关联，尤其是在老年患者和男性中。因此，为了降低肾脏进展的风险，我们建议临床医生鼓励患者改善身体活动。
