Casado Alfonso, López-de-Eguileta Alicia, Fonseca Soraya, Muñoz Pedro, Demetrio Rosalía, Gordo-Vega Miguel A, Cerveró Andrea
Department of Ophthalmology, Hospital Universitario Marqués de Valdecilla-IDIVAL, 39008 Santander, Spain.
Biomedicines. 2020 Mar 4;8(3):54. doi: 10.3390/biomedicines8030054.
In hydroxychloroquine (HCQ) retinopathy, early detection of asymptomatic retinal changes and the interruption of the drug are essential to prevent permanent vision loss. Our purpose was to investigate the roles of ganglion cell layer (GCL) and outer nuclear layer (ONL) thicknesses measured by optical coherence tomography (OCT) in the early diagnosis of retinopathy. One hundred and fourteen eyes of 76 individuals with HCQ treatment were enrolled in the study (42 eyes with impaired visual field (VF) and 72 eyes with nondamaged VF). We found that ONL was significantly decreased in the HCQ retinopathy group compared with the control group in the nasal macula ( = 0.032) as well as in four sectors ( < 0.044), whereas no significant differences were found comparing GCL in both groups. If VF were altered superiorly or temporarily, ONL was significantly thinned inferiorly ( = 0.029) and nasally ( = 0.008), respectively. Duration of HCQ treatment was significantly related with ONL in seven sectors of ONL ( < 0.047). We suggest that ONL measured with OCT might be used to assess early HCQ retinal toxicity.
在羟氯喹（HCQ）视网膜病变中，早期发现无症状的视网膜变化并中断用药对于预防永久性视力丧失至关重要。我们的目的是研究通过光学相干断层扫描（OCT）测量的神经节细胞层（GCL）和外核层（ONL）厚度在视网膜病变早期诊断中的作用。本研究纳入了76例接受HCQ治疗患者的114只眼（42只视野（VF）受损眼和72只VF未受损眼）。我们发现，与对照组相比，HCQ视网膜病变组鼻侧黄斑区的ONL显著降低（ = 0.032），四个象限也有显著降低（ < 0.044），而两组GCL比较无显著差异。如果VF上方或暂时改变，ONL分别在下方（ = 0.029）和鼻侧（ = 0.008）显著变薄。HCQ治疗持续时间与ONL的七个象限显著相关（ < 0.047）。我们认为，用OCT测量的ONL可用于评估早期HCQ视网膜毒性。
