各种结肠镜检查邀请方法在结直肠癌的早期发现和预防中的有效性如何？系统评价方案。
What is the effectiveness of various invitation methods to a colonoscopy in the early detection and prevention of colorectal cancer? Protocol of a systematic review.
机构信息
Institute of General Practice and Family Medicine, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Department of General Practice, Medical Faculty, University of Leipzig, Leipzig, Germany.
出版信息
Syst Rev. 2020 Mar 6;9(1):49. doi: 10.1186/s13643-020-01312-x.
BACKGROUND
Colorectal cancer, a prevalent malignancy worldwide, is associated with numerous modifiable and non-modifiable risk factors that play a role in the early detection and successful treatment of cancer. Despite improvements in the availability and quality of screening methods, especially colonoscopy, and the substantial survival benefits of the early detection of colorectal cancer, patient participation remains low due to clinical reasons and patient barriers. Studies around the world have used various methods of invitation in order to promote patient uptake of colonoscopies. The main objective of this systematic review is to analyze the association between certain invitation procedures, the participation in colonoscopies, and important patient outcomes in the early detection and prevention of colorectal cancer.
METHOD
We will systematically search in electronic databases including Medline via PubMed and Ovid, Cumulative Index of Nursing and Allied Health Literature (CINAHL), and the Cochrane Library. All studies will be described in a table of study characteristics with a risk of bias assessment. In addition, two authors will independently rate the overall quality of evidence for the critical outcomes using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) Working Group approach. Discrepancies regarding the inclusion of studies, data extraction, or risk of bias assessment will be resolved independently by one other reviewer. Due to the heterogeneous design of the studies that will be evaluated in this review, synthesizing data from these studies in the form of a meta-analysis may not be possible. In this instance, we can conduct a descriptive synthesis of data from these studies.
DISCUSSION
The results that arise from this systematic review will reflect the influence that various invitation procedures to a colonoscopy have on patient participation in these screenings. Drawing conclusions about the efficiency of various invitation methods to a colonoscopy can provide valuable information to both clinicians and patients and may not only improve future invitation-based patient recruitment to colonoscopy screenings, but also shape guidelines regarding prevention of colorectal cancer.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42019128645.
背景
结直肠癌是一种在全球范围内普遍存在的恶性肿瘤，与许多可改变和不可改变的危险因素有关，这些因素在癌症的早期发现和成功治疗中发挥作用。尽管筛查方法的可及性和质量有所提高，尤其是结肠镜检查，并且早期发现结直肠癌可以显著提高生存率，但由于临床原因和患者障碍，患者参与度仍然较低。世界各地的研究已经使用了各种邀请方法，以促进患者接受结肠镜检查。本系统评价的主要目的是分析某些邀请程序与结直肠癌早期发现和预防中患者参与结肠镜检查以及重要患者结局之间的关联。
方法
我们将系统地在电子数据库中进行搜索，包括通过 PubMed 和 Ovid 进行的 Medline、护理和联合健康文献累积索引（CINAHL）以及 Cochrane 图书馆。所有研究都将在研究特征表中进行描述，并对偏倚风险进行评估。此外，两名作者将使用推荐评估、制定与评估分级（GRADE）工作组方法独立评估关键结局的总体证据质量。对于研究纳入、数据提取或偏倚风险评估的分歧，将由另一位评审员独立解决。由于本评价中评估的研究设计存在异质性，因此可能无法以荟萃分析的形式综合这些研究的数据。在这种情况下，我们可以对这些研究的数据进行描述性综合。
讨论
本系统评价产生的结果将反映各种结肠镜检查邀请程序对患者参与这些筛查的影响。得出关于各种结肠镜检查邀请方法效率的结论可以为临床医生和患者提供有价值的信息，不仅可以提高未来基于邀请的结肠镜检查患者招募，还可以为结直肠癌预防指南提供依据。
系统评价注册
PROSPERO CRD42019128645。
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