在 350-1050nm 范围内，眼壁、巩膜和玻璃体的压力依赖直接组织间传递。

Pressure dependent direct transtissue transmission of eyewall, sclera and vitreous body in the range of 350-1050nm.

机构信息

Institute of Medical Engineering and Mechatronics, Ulm University of Applied Sciences, Albert-Einstein-Allee 55, D-89081 Ulm, Germany.

Pharmpur GmbH, Messerschmittring 33, D-86343 Koenigsbrunn, Germany.

出版信息

Z Med Phys. 2020 Aug;30(3):201-210. doi: 10.1016/j.zemedi.2020.02.003. Epub 2020 Mar 4.

DOI:10.1016/j.zemedi.2020.02.003

PMID:32143979

Abstract

PURPOSE

For transscleral application of optical radiation or light to the eye, it is important to know the transmission and absorbance of the tissue layers of the eyewall. The impact of photochemical energy to the retina located directly at the point of contact with the radiation emitter must be considered as well as the absorbance in choroid and retina. Therefore, the direct transmission of ex vivo porcine eyewalls and vitreous body were measured in this study.

METHODS

At ex vivo porcine eyes (N=221) pressure dependent transmission measurements were performed with a pressure inducing setup. Pressure and wavelength dependent direct transmission of eyewall and vitreous body of porcine eyes were described for different applied pressures (23mmHg, 78mmHg and 132mmHg). The transmissions were investigated within the spectral range of 350-1050nm. In addition to the complete eyewall transmission measurements, the transmission of sclera, vitreous body and water was measured individually and the transmission of retina and choroid was calculated.

RESULTS

With increasing wavelength and pressure, a significant transmission increase of the eyewall could be achieved (p<0.05). At 400nm and 132mmHg the transmission raised to 0.10%. At 1050nm it increased up to a value of 12.22%. In the visible spectrum, the direct transmission was always below 3.17%. The differences in eyewall transmission of eyes with different iris colors were significant at low pressure. With increasing pressure, the effect strength decreased and the differences lost their significance.

CONCLUSIONS

The pressure and wavelength dependent direct transmission of the eyewall and the vitreous body significantly increased with increasing pressure. This results are benefical for technical and clinical safety, research and development of illumination devices. It is necessary to know the intraocular brightness in the eye during diaphanoscopy, photocoagulation application to determine hazards.

摘要

目的

对于经巩膜应用光学辐射或光至眼睛，了解眼壁组织层的传输和吸收率非常重要。必须考虑到位于与辐射发射器直接接触点的视网膜的光化学生物能吸收以及脉络膜和视网膜的吸收率。因此，本研究测量了离体猪眼壁的直接透射率。

方法

在离体猪眼（N=221）上，使用压力诱导装置进行压力依赖性透射率测量。描述了不同应用压力（23mmHg、78mmHg 和 132mmHg）下眼壁和玻璃体的直接压力和波长依赖性透射率。在 350-1050nm 的光谱范围内进行了透射率研究。除了完整的眼壁透射率测量外，还单独测量了巩膜、玻璃体和水的透射率，并计算了视网膜和脉络膜的透射率。

结果

随着波长和压力的增加，眼壁的透射率显著增加（p<0.05）。在 400nm 和 132mmHg 时，透射率提高到 0.10%。在 1050nm 时，它增加到 12.22%。在可见光谱范围内，直接透射率始终低于 3.17%。不同虹膜颜色的眼睛的眼壁透射率差异在低压力下显著。随着压力的增加，效应强度降低，差异失去意义。