Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, The Netherlands.
FEBS Lett. 2020 Aug;594(16):2556-2569. doi: 10.1002/1873-3468.13767. Epub 2020 Mar 19.
Staphylococcus aureus and Staphylococcus epidermidis can cause many types of infections, ranging from skin infections to implant-associated infections. The primary innate immune response against bacterial infections involves complement activation, recruitment of phagocytes (most importantly neutrophils), and subsequent killing of the pathogen. However, staphylococci are not innocent bystanders; they actively obstruct this immune attack. To do that, S. aureus secretes several immune-evasion proteins to resist attack by the innate immune system. Furthermore, S. aureus and S. epidermidis are known for their ability to form biofilms on implanted medical devices and host tissues, which provides another important immune-evasion mechanism. Understanding these different strategies to resist immune attack will help to develop novel therapies against staphylococcal infections.
金黄色葡萄球菌和表皮葡萄球菌可引起多种类型的感染，从皮肤感染到植入物相关感染。针对细菌感染的主要先天免疫反应涉及补体激活、吞噬细胞（最重要的是中性粒细胞）的募集，以及随后对病原体的杀伤。然而，葡萄球菌并非无辜的旁观者；它们积极地阻碍这种免疫攻击。为此，金黄色葡萄球菌分泌几种免疫逃避蛋白来抵抗先天免疫系统的攻击。此外，金黄色葡萄球菌和表皮葡萄球菌以其在植入医疗器械和宿主组织上形成生物膜的能力而闻名，这提供了另一种重要的免疫逃避机制。了解这些不同的抵抗免疫攻击的策略将有助于开发针对葡萄球菌感染的新疗法。
