Coenye Tom, Ahonen Merja, Anderson Skip, Cámara Miguel, Chundi Parvathi, Fields Matthew, Foidl Ines, Gnimpieba Etienne Z, Griffin Kristen, Hinks Jamie, Loka Anup R, Lushbough Carol, MacPhee Cait, Nater Natasha, Raval Rasmita, Slater-Jefferies Jo, Teo Pauline, Wilks Sandra, Yung Maria, Webb Jeremy S
Laboratory of Pharmaceutical Microbiology, Ghent University, Belgium.
ESCMID Study Group on Biofilms (ESGB), Basel, Switzerland.
Biofilm. 2024 Jul 4;8:100210. doi: 10.1016/j.bioflm.2024.100210. eCollection 2024 Dec.
Priority question exercises are increasingly used to frame and set future research, innovation and development agendas. They can provide an important bridge between the discoveries, data and outputs generated by researchers, and the information required by policy makers and funders. Microbial biofilms present huge scientific, societal and economic opportunities and challenges. In order to identify key priorities that will help to advance the field, here we review questions from a pool submitted by the international biofilm research community and from practitioners working across industry, the environment and medicine. To avoid bias we used computational approaches to group questions and manage a voting and selection process. The outcome of the exercise is a set of 78 unique questions, categorized in six themes: (i) Biofilm control, disruption, prevention, management, treatment (13 questions); (ii) Resistance, persistence, tolerance, role of aggregation, immune interaction, relevance to infection (10 questions); (iii) Model systems, standards, regulatory, policy education, interdisciplinary approaches (15 questions); (iv) Polymicrobial, interactions, ecology, microbiome, phage (13 questions); (v) Clinical focus, chronic infection, detection, diagnostics (13 questions); and (vi) Matrix, lipids, capsule, metabolism, development, physiology, ecology, evolution environment, microbiome, community engineering (14 questions). The questions presented are intended to highlight opportunities, stimulate discussion and provide focus for researchers, funders and policy makers, informing future research, innovation and development strategy for biofilms and microbial communities.
优先级问题练习越来越多地用于构建和设定未来的研究、创新与发展议程。它们能够在研究人员所产生的发现、数据及成果与政策制定者和资助者所需的信息之间搭建起一座重要的桥梁。微生物生物膜带来了巨大的科学、社会和经济机遇与挑战。为了确定有助于推动该领域发展的关键优先事项，我们在此回顾了国际生物膜研究界以及跨行业、环境和医学领域的从业者提交的一系列问题。为避免偏差，我们采用了计算方法对问题进行分组，并管理投票和筛选过程。此次练习的结果是一组78个独特的问题，分为六个主题：（i）生物膜控制、破坏、预防、管理、治疗（13个问题）；（ii）抗性、持久性、耐受性、聚集作用、免疫相互作用、与感染的相关性（10个问题）；（iii）模型系统、标准、监管、政策教育、跨学科方法（15个问题）；（iv）多微生物、相互作用、生态学、微生物组、噬菌体（13个问题）；（v）临床重点、慢性感染、检测、诊断（13个问题）；以及（vi）基质、脂质、荚膜、代谢、发育、生理学、生态学、进化环境、微生物组、群落工程（14个问题）。所提出的这些问题旨在突出机遇、激发讨论，并为研究人员、资助者和政策制定者提供重点，为生物膜和微生物群落的未来研究、创新与发展战略提供信息。
