Parsons Joshua B, Mourad Ahmad, Conlon Brian P, Kielian Tammy, Fowler Vance G
Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Duke Clinical Research Institute, Duke University, Durham, NC, USA.
Nat Rev Microbiol. 2025 Aug 20. doi: 10.1038/s41579-025-01226-2.
Staphylococcus aureus is capable of infecting every organ system in the body and developing resistance to every available antibiotic used to treat it, such as methicillin-resistant S. aureus (commonly referred to as MRSA). This pathogen is characterized by the sudden emergence of virulent new clones and an array of mechanisms to circumvent the immune system and antibiotics. Furthermore, despite the development of new antibiotics and a growing body of high-quality data to inform their use, S. aureus continues to be a leading bacterial cause of death worldwide. In this Review, we provide an overview of the basic research on the complex interplay between S. aureus, the host and antibiotics. We also provide an update on the contemporary clinical studies on the treatment and prevention of S. aureus.
金黄色葡萄球菌能够感染人体的每个器官系统，并对用于治疗它的每种现有抗生素产生耐药性，例如耐甲氧西林金黄色葡萄球菌（通常称为MRSA）。这种病原体的特征是突然出现毒性新克隆以及一系列规避免疫系统和抗生素的机制。此外，尽管开发了新抗生素并积累了越来越多的高质量数据以指导其使用，但金黄色葡萄球菌仍然是全球主要的细菌性死亡原因。在本综述中，我们概述了关于金黄色葡萄球菌、宿主和抗生素之间复杂相互作用的基础研究。我们还提供了关于金黄色葡萄球菌治疗和预防的当代临床研究的最新情况。
