Kauppinen-Mäkelin R, Nikkilä E A
Third Department of Medicine, University of Helsinki, Finland.
Atherosclerosis. 1988 Nov;74(1-2):65-74. doi: 10.1016/0021-9150(88)90192-x.
The lipid and lipoprotein profile was examined in male patients with acute myocardial infarction (AMI) at the time of infarction (group A) and in male patients who had survived AMI 2-3 years before the study (group B), and compared to that of healthy controls. The myocardial infarction (MI) patients exhibited similar total cholesterol and LDL-cholesterol levels as the controls. However, the LDL mass concentration was higher in patients than in controls (P less than 0.01 for group A, P less than 0.001 for group B). In composition, patients' LDL in both groups was rich in protein and triglycerides but poor in cholesterol. The compositional changes in patient LDL were evident at all levels of LDL-cholesterol. The mean total HDL and HDL2 mass concentrations were lower in patients than in controls (P less than 0.001 for both groups), but there was no difference in HDL3 levels. Upon admission to hospital the patients with AMI at the time of examination (group A) had higher serum total triglyceride concentration than controls, but on the fasting morning samples serum triglyceride and VLDL lipid levels did not differ between patients and controls. Patients who had survived AMI 2-3 years prior to study (group B) exhibited higher serum total triglyceride and VLDL levels than the control subjects. On stepwise discriminant analysis, HDL2 protein concentration was the single best variable for distinguishing between patients and controls. The most powerful discriminatory parameter was the HDL/LDL protein ratio or the HDL2/LDL protein ratio.
对急性心肌梗死（AMI）男性患者在梗死时（A组）以及在研究前2 - 3年曾患AMI且存活下来的男性患者（B组）进行了血脂和脂蛋白分析，并与健康对照组进行比较。心肌梗死（MI）患者的总胆固醇和低密度脂蛋白胆固醇水平与对照组相似。然而，患者的低密度脂蛋白质量浓度高于对照组（A组P小于0.01，B组P小于0.001）。在组成方面，两组患者的低密度脂蛋白富含蛋白质和甘油三酯，但胆固醇含量低。患者低密度脂蛋白的组成变化在所有低密度脂蛋白胆固醇水平上都很明显。患者的平均总高密度脂蛋白和高密度脂蛋白2质量浓度低于对照组（两组均P小于0.001），但高密度脂蛋白3水平无差异。在检查时，急性心肌梗死患者（A组）入院时血清总甘油三酯浓度高于对照组，但在空腹早晨样本中，患者与对照组之间的血清甘油三酯和极低密度脂蛋白脂质水平无差异。在研究前2 - 3年曾患AMI且存活下来的患者（B组）血清总甘油三酯和极低密度脂蛋白水平高于对照组。在逐步判别分析中，高密度脂蛋白2蛋白质浓度是区分患者与对照组的最佳单一变量。最有力的判别参数是高密度脂蛋白/低密度脂蛋白蛋白质比率或高密度脂蛋白2/低密度脂蛋白蛋白质比率。
