Murai A, Miyahara T, Tanaka T, Kameyama M
Tohoku J Exp Med. 1986 Jan;148(1):57-64. doi: 10.1620/tjem.148.57.
To characterize the plasma lipoproteins in survivors of cerebral infarction, plasma lipoproteins were ultracentrifugally fractionated into VLDL, LDL, HDL2 and HDL3, and the concentrations of cholesterol, phospholipid, apolipoprotein and triglyceride in each lipoprotein class were determined. Subjects examined were 15 male healthy controls and 15 male survivors of cerebral infarction situated in the distribution of cerebral cortical artery. The concentrations of VLDL-cholesterol and VLDL-triglyceride and the percent content of VLDL-cholesterol were higher in survivors than in controls. The concentration of LDL-triglyceride was higher and the percent content of LDL-cholesterol was lower in survivors than in controls. While the plasma concentration of triglyceride was higher in survivors than in controls, those of HDL, HDL2 and HDL3 were lower in survivors. The concentrations of cholesterol, phospholipid and apolipoprotein in either HDL2 or HDL3 were also reduced in survivors as compared with controls. In either HDL2 or HDL3, the percent content of triglyceride was higher and that of phospholipid was lower in survivors than in controls. These results were in good agreement with those reported for survivors of myocardial infarction, suggesting that the underlying derangement in lipoprotein metabolism is common to myocardial and cerebral infarction.
为了表征脑梗死幸存者的血浆脂蛋白，通过超速离心将血浆脂蛋白分离为极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）、高密度脂蛋白2（HDL2）和高密度脂蛋白3（HDL3），并测定各脂蛋白组分中胆固醇、磷脂、载脂蛋白和甘油三酯的浓度。研究对象为15名男性健康对照者和15名位于大脑皮质动脉分布区的男性脑梗死幸存者。脑梗死幸存者的极低密度脂蛋白胆固醇和极低密度脂蛋白甘油三酯浓度以及极低密度脂蛋白胆固醇的百分比含量均高于对照组。脑梗死幸存者的低密度脂蛋白甘油三酯浓度较高，而低密度脂蛋白胆固醇的百分比含量较低。虽然脑梗死幸存者的血浆甘油三酯浓度高于对照组，但其高密度脂蛋白、高密度脂蛋白2和高密度脂蛋白3的浓度低于对照组。与对照组相比，脑梗死幸存者的高密度脂蛋白2或高密度脂蛋白3中的胆固醇、磷脂和载脂蛋白浓度也降低。在高密度脂蛋白2或高密度脂蛋白3中，脑梗死幸存者的甘油三酯百分比含量较高，而磷脂百分比含量较低。这些结果与心肌梗死幸存者的报道结果高度一致，表明脂蛋白代谢的潜在紊乱在心肌梗死和脑梗死中是常见的。
