Murai A, Miyahara T, Tanaka T, Sako Y, Nishimura N, Kameyama M
Artery. 1985;12(4):234-43.
A daily 1000 mg of pantethine was orally administered to 12 male survivors of cerebral infarction for 3 months. Before and after the medication, plasma lipoproteins were ultracentrifugally separated. Plasma concentrations of total cholesterol, triglyceride, phospholipid, and VLDL- and LDL-cholesterol tended to decrease. On the contrary, HDL-cholesterol concentration and HDL:LDL-cholesterol ratio significantly increased. HDL2-cholesterol concentration significantly increased, whereas HDL3-cholesterol concentration remained unchanged, resulting in a significant elevation of HDL2:HDL3-cholesterol ratio. In HDL2 the percentage content of cholesterol and triglyceride decreased, while that of phospholipid increased. However, no significant changes were found in the chemical composition of HDL3. The plasma concentrations of apo A-I and, to a lesser extent, A-II increased, with a slight increase in A-I:A-II ratio but A-I:A-II ratio in either HDL2 or HDL3 remained unchanged.
对12名男性脑梗死幸存者口服给予每日1000毫克泛硫乙胺，持续3个月。用药前后，通过超速离心法分离血浆脂蛋白。总胆固醇、甘油三酯、磷脂以及极低密度脂蛋白胆固醇和低密度脂蛋白胆固醇的血浆浓度呈下降趋势。相反，高密度脂蛋白胆固醇浓度和高密度脂蛋白与低密度脂蛋白胆固醇比值显著升高。高密度脂蛋白2胆固醇浓度显著升高，而高密度脂蛋白3胆固醇浓度保持不变，导致高密度脂蛋白2与高密度脂蛋白3胆固醇比值显著升高。在高密度脂蛋白2中，胆固醇和甘油三酯的百分比含量下降，而磷脂的百分比含量增加。然而，高密度脂蛋白3的化学成分未发现显著变化。载脂蛋白A-I的血浆浓度以及程度较轻的载脂蛋白A-II的血浆浓度升高，A-I与A-II比值略有增加，但高密度脂蛋白2或高密度脂蛋白3中的A-I与A-II比值保持不变。
