Laboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garças, Mato Grosso State, Brazil; Laboratory of Experimental Research on Gynecology and Obstetrics, Postgraduate Course on Tocogynecology, Univ Estadual Paulista_Unesp, Botucatu, São Paulo State, Brazil.
Laboratory of Experimental Research on Gynecology and Obstetrics, Postgraduate Course on Tocogynecology, Univ Estadual Paulista_Unesp, Botucatu, São Paulo State, Brazil.
J Ethnopharmacol. 2020 May 23;254:112728. doi: 10.1016/j.jep.2020.112728. Epub 2020 Mar 4.
Phyllanthus niruri is a well-known plant for its therapeutic purposes to treat various diseases, being widely used by the population, mainly by women. However, there is no scientific confirmation of the effects of use during pregnancy.
Evaluating the effect of Phyllanthus niruri aqueous extract on the maternal toxicity, reproductive outcomes and fetal anomaly incidence in rats.
Pregnant rats were distributed into four experimental groups: Control = treated with water (vehicle); Treated 150 = treated with P. niruri at dose 150 mg/kg and; Treated 300 = treated with P. niruri at dose 300 mg/kg; and Treated 600 = treated with P. niruri at dose 600 mg/kg. The rats were treated by intragastric route (gavage) with P. niruri or vehicle (water) from gestational day 0 to 21. At day 21 of pregnancy, maternal reproductive outcomes, biochemical profile and maternal renal tissue were evaluated. The fetuses and placentas were collected and analyzed.
Treatment with P. niruri did not alter the reproductive performance outcomes of rats. However, treated 600 group presented with changes in maternal kidney weight and morphology. The plant did not present teratogenic effect, but caused fetal macrosomia and increased ossification sites.
Treatment with aqueous extract of P. niruri administered during gestation did not cause reproductive toxicity, but led to changes in maternal kidneys and in offspring weight, showing that the leaf extract of this plant can produce detrimental effects during pregnancy.
藤黄属植物因其治疗各种疾病的治疗用途而广为人知，被广泛应用于人群，主要是女性。然而，目前尚无科学证据证实其在怀孕期间使用的效果。
评估 Phyllanthus niruri 水提物对大鼠母体毒性、生殖结局和胎儿畸形发生率的影响。
将怀孕的大鼠分为四个实验组：对照组=用（载体）水治疗；处理 150=用 150mg/kg 的 P. niruri 治疗；处理 300=用 300mg/kg 的 P. niruri 治疗；处理 600=用 600mg/kg 的 P. niruri 治疗。大鼠从妊娠第 0 天到第 21 天通过灌胃途径（经口）用 P. niruri 或载体（水）治疗。在妊娠第 21 天，评估母体生殖结局、生化特征和母体肾脏组织。收集并分析胎儿和胎盘。
用 P. niruri 治疗并未改变大鼠的生殖性能结果。然而，处理 600 组的母体肾脏重量和形态发生变化。该植物没有致畸作用，但导致胎儿巨大儿和骨化部位增加。
在妊娠期间给予 Phyllanthus niruri 水提取物治疗不会引起生殖毒性，但会导致母体肾脏和后代体重发生变化，表明该植物的叶提取物在怀孕期间可能产生有害影响。
