Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mult Scler Relat Disord. 2020 Jun;41:102030. doi: 10.1016/j.msard.2020.102030. Epub 2020 Feb 27.
We describe a case of an unusually early and severe manifestation of Aquaporin-4 (AQP-4) positive Neuromyelitis Optica Spectrum Disorder (NMOSD) in a two-year-old girl. We discuss learning points from her clinical presentation and highlight differences between pediatric and adult presentations of the disease. We argue that AQP-4 NMOSD should always be considered in the differential diagnosis for any child presenting with an acute neuroimmunological process given the morbidity associated with the condition and the importance of early diagnosis and treatment.
我们描述了一例两周岁女童发生水通道蛋白 4（AQP-4）阳性视神经脊髓炎谱系疾病（NMOSD）的极早且严重表现。我们讨论了她临床表现的学习要点，并强调了该疾病在儿科和成人患者中的表现差异。我们认为，鉴于该疾病的发病率以及早期诊断和治疗的重要性，对于任何出现急性神经免疫过程的儿童，均应考虑将 AQP-4 NMOSD 纳入鉴别诊断。
