Helle M, Helin H, Isola J, Krohn K
Mikkeli Central Hospital, Finland.
APMIS. 1988 Dec;96(12):1140-2. doi: 10.1111/j.1699-0463.1988.tb00992.x.
In a study of 86 human breast cancers the volume fraction of the neoplastic epithelium was estimated semiquantitatively and a significant association was found between the oestrogen receptor (ER) content and volume fraction of cancer cells of tumours (p less than 0.00001). Tumours with very low cellularity could thus be falsely ER negative. When quantitative ER concentration is used to predict the response of tumours to hormonal therapy the cellularity of tumours should be taken in consideration. The cellularity was not related to ER positivity. Although a correlation was seen between the contents of oestrogen and progesterone (PR) receptors, no correlation between PR content and volume fraction of the neoplastic epithelium was observed.
在一项对86例人类乳腺癌的研究中，对肿瘤上皮的体积分数进行了半定量估计，发现雌激素受体（ER）含量与肿瘤癌细胞的体积分数之间存在显著关联（p小于0.00001）。细胞含量非常低的肿瘤可能因此被错误地判定为ER阴性。当使用定量ER浓度来预测肿瘤对激素治疗的反应时，应考虑肿瘤的细胞含量。细胞含量与ER阳性无关。尽管观察到雌激素和孕激素（PR）受体含量之间存在相关性，但未观察到PR含量与肿瘤上皮体积分数之间的相关性。
