Thoresen S, Thorsen T, Tangen M, Hartveit F
Breast Cancer Res Treat. 1982;2(3):251-5. doi: 10.1007/BF01806938.
Histological grading of 160 primary infiltrating breast carcinomas showed that both oestrogen and progesterone receptor status are strongly related to grade, tumours that are receptor positive tending to be of lower grade than the receptor negative. The nuclear factors used in grading were those that determined this association. In addition the absence/presence of both receptors was reflected in the grade present, beyond the correlation expected on the basis of either receptor alone.
对160例原发性浸润性乳腺癌进行组织学分级，结果显示雌激素和孕激素受体状态均与分级密切相关，受体阳性的肿瘤往往比受体阴性的肿瘤分级更低。分级所使用的核因子正是决定这种关联的因素。此外，两种受体的缺失/存在情况在现有的分级中有所体现，这超出了仅基于单一受体所预期的相关性。
