Brehm Bonnie, Summer Suzanne, Jenkins Todd, D'Alessio David, Inge Thomas
College of Nursing, University of Cincinnati, Cincinnati, Ohio.
Schubert Research Clinic, Cincinnati Children's Hospital Medical Center Cincinnati, Cincinnati, Ohio.
Surg Obes Relat Dis. 2020 May;16(5):599-606. doi: 10.1016/j.soard.2020.01.025. Epub 2020 Feb 4.
Few studies have addressed the effect of bariatric surgery on factors related to energy balance, including resting energy expenditure (REE) and thermic effect of food (TEF). To our knowledge, very few studies have examined changes in REE and none have investigated modifications in TEF after sleeve gastrectomy (SG) performed in adolescents.
To assess energy expenditure in females who underwent SG as adolescents and matched-control participants as preliminary data about the potential of SG to confer differences in postprandial energy expenditure.
Children's Hospital Medical Center, Cincinnati, Ohio, United States.
In this observational study, REE and respiratory quotient (RQ) were measured via indirect calorimetry, followed by a standardized meal and assessment of TEF and postprandial RQ. Plasma drawn before and every 15 minutes after the meal was assayed for insulin, glucose, and C-peptide. Usual dietary intake was estimated using 24-hour recall interviews.
Fasting REE and RQ were similar between surgical and control groups. Postmeal TEF also did not differ between groups. The surgical group had higher RQ early in the postprandial period, whereas the control group RQ was higher after 125 minutes post meal. Compared with the control group, the surgical group had lower postprandial glucose, higher insulin and C-peptide, and consumed less daily energy during usual intake.
Postprandial RQ was consistent with the rapid gastric emptying typical of SG, yet we observed no group differences in REE or TEF. These findings may have been due to limited statistical power. More comprehensive studies of EE after SG are warranted.
很少有研究探讨减肥手术对与能量平衡相关因素的影响，包括静息能量消耗（REE）和食物热效应（TEF）。据我们所知，极少有研究检测过REE的变化，且尚无研究调查青少年接受袖状胃切除术（SG）后TEF的改变。
评估青少年时期接受SG手术的女性及匹配的对照参与者的能量消耗，作为关于SG在餐后能量消耗方面产生差异可能性的初步数据。
美国俄亥俄州辛辛那提市儿童医院医疗中心。
在这项观察性研究中，通过间接测热法测量REE和呼吸商（RQ），随后给予标准化餐食并评估TEF和餐后RQ。在餐前及餐后每隔15分钟采集的血浆样本检测胰岛素、葡萄糖和C肽。通过24小时回顾性访谈估算日常饮食摄入量。
手术组和对照组的空腹REE和RQ相似。两组之间餐后TEF也无差异。手术组在餐后早期RQ较高，而对照组在餐后125分钟后RQ较高。与对照组相比，手术组餐后血糖较低，胰岛素和C肽较高，且在日常饮食摄入中每日消耗的能量较少。
餐后RQ与SG典型的快速胃排空一致，但我们观察到REE或TEF在两组之间并无差异。这些发现可能是由于统计效力有限。有必要对SG术后的能量消耗进行更全面的研究。
