Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA, 94107, USA.
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Skeletal Radiol. 2020 Sep;49(9):1359-1368. doi: 10.1007/s00256-020-03409-9. Epub 2020 Mar 7.
To investigate the associations of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with changes in knee cartilage composition and joint structure over 48 months, using magnetic resonance imaging (MRI) data from the Osteoarthritis Initiative (OAI).
A total of 1126 participants with right knee Kellgren-Lawrence (KL) score 0-2 at baseline, no history of rheumatoid arthritis, blood pressure measurements at baseline, and cartilage T2 measurements at baseline and 48 months were selected from the OAI. Cartilage composition was assessed using MRI T2 measurements, including laminar and gray-level co-occurrence matrix texture analyses. Structural knee abnormalities were graded using the whole-organ magnetic resonance imaging score (WORMS). We performed linear regression, adjusting for age, sex, body mass index, physical activity, smoking status, alcohol use, KL score, number of anti-hypertensive medications, and number of nonsteroidal anti-inflammatory drugs.
Higher baseline DBP was associated with greater increases in global T2 (coefficient 0.22 (95% CI 0.09, 0.34), P = 0.004), global superficial layer T2 (coefficient 0.39 (95% CI 0.20, 0.58), P = 0.001), global contrast (coefficient 15.67 (95% CI 8.81, 22.53), P < 0.001), global entropy (coefficient 0.02 (95% CI 0.01, 0.03) P = 0.011), and global variance (coefficient 9.14 (95% CI 5.18, 13.09), P < 0.001). Compared with DBP, the associations of SBP with change in cartilage T2 parameters and WORMS subscores showed estimates of smaller magnitude.
Higher baseline DBP was associated with higher and more heterogenous cartilage T2 values over 48 months, indicating increased cartilage matrix degenerative changes.
利用来自骨关节炎倡议（OAI）的磁共振成像（MRI）数据，研究收缩压（SBP）和舒张压（DBP）与 48 个月内膝关节软骨成分和关节结构变化的相关性。
从 OAI 中选择了 1126 名基线时右膝关节 Kellgren-Lawrence（KL）评分 0-2、无类风湿关节炎病史、基线时有血压测量值和基线及 48 个月时有软骨 T2 测量值的参与者。使用 MRI T2 测量评估软骨成分，包括层状和灰度共生矩阵纹理分析。使用全器官磁共振成像评分（WORMS）对结构异常的膝关节进行分级。我们进行了线性回归，调整了年龄、性别、体重指数、身体活动、吸烟状况、饮酒状况、KL 评分、抗高血压药物数量和非甾体抗炎药数量。
较高的基线 DBP 与全球 T2 增加呈正相关（系数 0.22（95% CI 0.09，0.34），P=0.004）、全球浅层 T2 增加（系数 0.39（95% CI 0.20，0.58），P=0.001）、全球对比度增加（系数 15.67（95% CI 8.81，22.53），P<0.001）、全球熵增加（系数 0.02（95% CI 0.01，0.03），P=0.011）和全球方差增加（系数 9.14（95% CI 5.18，13.09），P<0.001）。与 DBP 相比，SBP 与软骨 T2 参数和 WORMS 子评分变化的相关性显示出较小的估计值。
较高的基线 DBP 与 48 个月内更高和更异质的软骨 T2 值相关，表明软骨基质退行性变化增加。
