Nordin B E, Wishart J M, Horowitz M, Need A G, Bridges A, Bellon M
Division of Clinical Chemistry, Institute of Medical and Veterinary Science, Adelaide, SA, Australia.
Bone Miner. 1988 Oct;5(1):21-33. doi: 10.1016/0169-6009(88)90004-9.
Vertebral and forearm mineral density (VMD and FMD, respectively) were determined in 124 postmenopausal women with no crushed vertebrae or peripheral fractures, 51 who had sustained peripheral fractures only since the menopause, 62 with vertebral compression(s) only and 75 with both types of fracture. There was a very significant correlation between the two measurements in the whole set. The scatter could not be accounted for by methodological error but was partly accounted for by body weight, since VMD was related to body weight and FMD was not. Whatever criterion was used for the diagnosis of osteoporosis (whether fracture or density) the percentage of misclassified cases was very similar by the two methods. However, VMD was relatively more reduced than FMD in vertebral fracture cases and FMD was marginally more reduced than VMD in peripheral fracture cases. There is little to choose between vertebral and forearm density in the diagnosis of osteoporosis but vertebral densitometry is slightly superior to forearm densitometry in describing the severity of osteoporosis in vertebral fracture patients.
对124名无椎体压缩或外周骨折的绝经后女性、51名绝经后仅发生外周骨折的女性、62名仅发生椎体压缩的女性以及75名两种骨折均有的女性，分别测定了椎体和前臂骨密度（分别为VMD和FMD）。在整个研究组中，这两种测量结果之间存在非常显著的相关性。这种散点分布不能用方法学误差来解释，但部分可由体重来解释，因为VMD与体重有关，而FMD与体重无关。无论采用何种标准诊断骨质疏松症（无论是骨折还是骨密度），两种方法误诊病例的百分比非常相似。然而，在椎体骨折病例中，VMD相对比FMD降低得更多，而在外周骨折病例中，FMD比VMD略微降低得更多。在骨质疏松症的诊断中，椎体和前臂骨密度之间差别不大，但在描述椎体骨折患者骨质疏松症的严重程度方面，椎体骨密度测定略优于前臂骨密度测定。
