Książek Mariusz, Lewandowski Bogumił, Brodowski Robert, Pakla Paweł, Kawalec-Książek Marta, Fudali Ludmiła, Ryś Janusz
Department of Pathology, MedLifeCover, Krosno, Poland.
Department of Oral and Maxillofacial Surgery, Clinical Voivodeship Hospital Nr 1, Rzeszow, Poland.
Pol J Pathol. 2019;70(4):277-285. doi: 10.5114/pjp.2019.93130.
Currently there is being conducted an extensive search to find new prognostic factors in oral squamous cell carcinoma which would assist in better patient management. One of the most promising prognostic markers is the density of tumour infiltrating lymphocytes. 100 cases of patients with oral squamous cell carcinoma that underwent surgical resection between 2006 and June 2016 at our institution were included in this study. From each case the most representative HE stained slide was identified and the density of tumour infiltrating lymphocytes were classified as non-brisk or brisk, which was included in the survival analysis. Upon analysis there was a strong correlation between non-brisk (n = 28) and brisk (n = 72) tumour infiltrating lymphocytes and the primary clinical outcomes: overall survival (p = 0.0472) and local recurrence-free survival (p = 0.00037). Univariate and multivariate Cox regression model confirmed the high prognostic value of tumour infiltrating lymphocytes as the independent prognostic indicator of better survival, being even superior, in our study, to the traditional pTNM system. This study provides robust evidence that the density of tumour infiltrating lymphocytes demonstrates a high prognostic significance in oral squamous cell carcinoma.
目前正在进行广泛的研究，以寻找口腔鳞状细胞癌新的预后因素，这将有助于更好地管理患者。最有前景的预后标志物之一是肿瘤浸润淋巴细胞的密度。本研究纳入了2006年至2016年6月期间在我院接受手术切除的100例口腔鳞状细胞癌患者。从每个病例中确定最具代表性的苏木精-伊红（HE）染色切片，并将肿瘤浸润淋巴细胞的密度分为不活跃或活跃，纳入生存分析。分析发现，不活跃（n = 28）和活跃（n = 72）的肿瘤浸润淋巴细胞与主要临床结局之间存在强相关性：总生存期（p = 0.0472）和无局部复发生存期（p = 0.00037）。单因素和多因素Cox回归模型证实，肿瘤浸润淋巴细胞作为更好生存的独立预后指标具有较高的预后价值，在我们的研究中，甚至优于传统的pTNM系统。本研究提供了有力证据，表明肿瘤浸润淋巴细胞的密度在口腔鳞状细胞癌中具有较高的预后意义。
