The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China.
College of Environmental Science and Engineering, Hunan University, Changsha, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, China.
Complement Ther Med. 2020 Mar;49:102319. doi: 10.1016/j.ctim.2020.102319. Epub 2020 Jan 16.
This meta-analysis aimed to evaluate the comprehensive efficiency and safety of acupuncture on Luteinized Unruptured Follicle Syndrome based on Randomized Controlled Trials (RCTs).
Six electronic databases (i.e. Wanfang, VIP, China National Knowledge Infrastructure, Pubmed, Cochrane, and Embase) were searched from inception to July 2019. Randomized controlled trials were eligible to evaluate the effects of acupuncture alone or acupuncture as an adjunct. The primary outcomes were the ovulation rate and pregnancy rate. Two reviewers proceeded study selection and quality assessment of included trials and performed heterogeneity of included studies before meta-analysis.Trial Sequential Analysis was used to assess the risk of random error and estimate required information size. The Grading of Recommendations Assessment, Development and Evaluation was applied for assessing level of evidence.
10 studies involving 715 participants were included Meta-analysis showed acupuncture alone and acupuncture as an adjunct both could significantly improve ovulation, which were confirmed by Trial Sequential Analysis. The evidence of acupuncture improving pregnancy rate was insufficient. Improved serum luteinizing hormone and estradiol levels, and decreased pulsatility index and resistance index of ovary artery were shown in both two subgroups. Level of evidence of most outcomes was "low" or "very low", so the results should be cautiously interpreted.
Acupuncture alone or be combined with drugs are effective on Luteinized Unruptured Follicle Syndrome especially for improving ovulation . While concurrent evidence is insufficient, and further studies of high quality are needed to strengthen the conclusion.
本荟萃分析旨在评估基于随机对照试验（RCT）的针灸对未破裂黄素化卵泡综合征的综合疗效和安全性。
从建库到 2019 年 7 月，检索了 6 个电子数据库（即万方、VIP、中国知网、PubMed、Cochrane 和 Embase）。单独使用针灸或针灸作为辅助治疗的随机对照试验符合纳入标准。主要结局是排卵率和妊娠率。两名审阅者进行研究选择和纳入试验的质量评估，并在进行荟萃分析之前对纳入研究进行异质性分析。试验序贯分析用于评估随机误差的风险并估计所需的信息大小。推荐评估、制定与评价分级用于评估证据水平。
纳入了 10 项研究，共 715 名参与者。荟萃分析显示，单独使用针灸和针灸作为辅助治疗均能显著提高排卵率，这一结果通过试验序贯分析得到了证实。针灸提高妊娠率的证据不足。两个亚组均显示血清黄体生成素和雌二醇水平升高，卵巢动脉搏动指数和阻力指数降低。大多数结局的证据水平为“低”或“极低”，因此结果应谨慎解释。
单独使用针灸或与药物联合使用对未破裂黄素化卵泡综合征有效，尤其能改善排卵。但目前证据尚不足，需要高质量的进一步研究来加强结论。
