Godin Jean-Philippe, Martin Francois-Pierre, Breton Isabelle, Schoepfer Alain, Nydegger Andreas
Nestlé Research, Vers-chez-les-Blanc, PO BOX 44, 1000-6, Lausanne, Switzerland.
Nestlé Research, Vers-chez-les-Blanc, PO BOX 44, 1000-6, Lausanne, Switzerland.
Clin Nutr. 2020 Oct;39(10):3147-3152. doi: 10.1016/j.clnu.2020.02.003. Epub 2020 Feb 20.
Pediatric inflammatory bowel disease (IBD) is often associated with growth retardation due to malnutrition. However, knowledge on total energy expenditure (TEE), active-induced energy expenditure (AEE) and physical activity remains limited in children with IBD.
Assessment of TEE using the doubly labelled water (DLW) method, resting energy expenditure (REE) using indirect calorimetry, and physical activity level using the actigraph GT3X+ in children with IBD (in remission) and healthy controls.
TEE, REE, AEE and physical activity were measured in 21 children with IBD and 24 healthy controls at baseline. IBD children parameters were monitored further after 6 and 12 months. Predicted REE and TEE values (using Schoefield and the actigraph GT3X+, for REE and TEE respectively) were compared to measured values.
Mean ages at baseline were 14.8 ± 1.5 and 13.2 ± 2 years in children with IBD and in healthy control children, respectively. Measured TEE was significantly lower (P < 0.001) in children with IBD compared to the healthy control group. REE corrected by FFM, REE and AEE were also significantly lower in children with IBD. Children with IBD had AEE of 17.5% of TEE and had a significantly higher sedentary behaviour as compared to healthy children.
This study suggests that TEE and AEE are reduced in children with IBD in clinical remission which may result in a reduced moderate and vigorous physical activity level. Our result also highlights that the actigraph GT3X + might give good prediction of TEE in children with IBD at group level but it remains highly variable at individual level.
儿童炎症性肠病（IBD）常因营养不良而伴有生长发育迟缓。然而，关于IBD患儿的总能量消耗（TEE）、活动诱导能量消耗（AEE）和身体活动情况的了解仍然有限。
采用双标水（DLW）法评估IBD患儿（病情缓解期）和健康对照儿童的TEE，采用间接测热法评估静息能量消耗（REE），并使用活动记录仪GT3X+评估身体活动水平。
在基线时对21例IBD患儿和24例健康对照儿童测量TEE、REE、AEE和身体活动情况。对IBD患儿的参数在6个月和12个月后进一步监测。将预测的REE和TEE值（分别使用Schoefield公式和活动记录仪GT3X+预测REE和TEE）与测量值进行比较。
IBD患儿和健康对照儿童的基线平均年龄分别为14.8±1.5岁和13.2±2岁。与健康对照组相比，IBD患儿的测量TEE显著更低（P<0.001）。IBD患儿经去脂体重校正的REE、REE和AEE也显著更低。IBD患儿的AEE占TEE的17.5%，与健康儿童相比，久坐行为显著更多。
本研究表明，临床缓解期的IBD患儿TEE和AEE降低，这可能导致中度和剧烈身体活动水平降低。我们的结果还突出显示，活动记录仪GT3X+在群体水平上可能对IBD患儿的TEE有较好的预测作用，但在个体水平上仍存在很大差异。
