King J T, LaMotte C C
Section of Neurological Surgery, Yale University School of Medicine, New Haven, CT 06510.
Brain Res. 1988 Dec 13;475(1):192-7. doi: 10.1016/0006-8993(88)90218-1.
The El (epileptic) mouse is a model of hereditary sensory precipitated temporal lobe epilepsy. We compared vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI), somatostatin-like immunoreactivity (SS-LI), and gamma-aminobutyric acid-like immunoreactivity (GABA-LI) in the mid-hippocampal region of El and C57BL/6 mice. Specific interneuron populations with VIP-LI and GABA-LI were elevated in the El mice, whereas SS-LI populations were unchanged. These neurochemical alterations may be contributing to the epileptic predisposition of El mice.
El（癫痫）小鼠是遗传性感觉诱发性颞叶癫痫的一种模型。我们比较了El小鼠和C57BL/6小鼠海马中部区域的血管活性肠肽样免疫反应性（VIP-LI）、生长抑素样免疫反应性（SS-LI）和γ-氨基丁酸样免疫反应性（GABA-LI）。El小鼠中具有VIP-LI和GABA-LI的特定中间神经元群体增加，而SS-LI群体没有变化。这些神经化学改变可能导致了El小鼠的癫痫易感性。
