Wang Mei-Xia, Liuyu Tianzi, Zhang Zhi-Dong
The Executive Master of Business Administration (EMBA) Program, School of Management, Fudan University, Shanghai, China.
Department of Gastrointestinal Surgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan, China.
Front Immunol. 2022 Jun 30;13:936579. doi: 10.3389/fimmu.2022.936579. eCollection 2022.
Ubiquitination is a post-translational modification that plays essential roles in various physiological and pathological processes. Protein ubiquitination depends on E3 ubiquitin ligases that catalyze the conjugation of ubiquitin molecules on lysine residues of targeted substrates. RING finger protein 115 (RNF115), also known as breast cancer associated gene 2 (BCA2) and Rab7-interacting RING finger protein (Rabring7), has been identified as a highly expressed protein in breast cancer cells and tissues. Later, it has been demonstrated that RNF115 catalyzes ubiquitination of a series of proteins to modulate a number of signaling pathways, and thereby regulates viral infections, autoimmunity, cell proliferation and death and tumorigenesis. In this review, we introduce the identification, expression and activity regulation of RNF115, summarize the substrates and functions of RNF115 in different pathways, and discuss the roles of RNF115 as a biomarker or therapeutic target in diseases.
泛素化是一种翻译后修饰，在各种生理和病理过程中发挥着重要作用。蛋白质泛素化依赖于E3泛素连接酶，该酶催化泛素分子与靶向底物的赖氨酸残基结合。环指蛋白115（RNF115），也被称为乳腺癌相关基因2（BCA2）和Rab7相互作用环指蛋白（Rabring7），已被鉴定为在乳腺癌细胞和组织中高表达的蛋白质。后来，已证明RNF115催化一系列蛋白质的泛素化，以调节多种信号通路，从而调节病毒感染、自身免疫、细胞增殖和死亡以及肿瘤发生。在本综述中，我们介绍了RNF115的鉴定、表达和活性调节，总结了RNF115在不同途径中的底物和功能，并讨论了RNF115作为疾病生物标志物或治疗靶点的作用。
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