Dermatology Service, Ciudad Real General University Hospital, Ciudad Real, Spain.
School of Dentistry, University of Granada, Granada, Spain.
Pigment Cell Melanoma Res. 2020 Nov;33(6):788-805. doi: 10.1111/pcmr.12874. Epub 2020 Mar 20.
Cyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is upregulated in several types of human tumors including melanoma and is currently classified as an oncogene that promotes uncontrolled cell proliferation. Despite the demonstrated importance of CCND1/cyclin D1 as a central oncogene in several types of human tumors, its knowledge in melanoma is still limited. This review examines data published on upregulation of the CCND1 gene and cyclin D1 protein in the melanoma setting, focusing on the pathways and molecular mechanisms involved in the activation of the gene and on the clinical and therapeutic implications.
细胞周期蛋白 D1 是由 CCND1 基因编码的蛋白质，位于 11q13 染色体上，是细胞周期生理调节的关键组成部分。CCND1/细胞周期蛋白 D1 在包括黑色素瘤在内的几种人类肿瘤中上调，目前被归类为促进不受控制的细胞增殖的癌基因。尽管 CCND1/细胞周期蛋白 D1 作为几种人类肿瘤中的中心癌基因的重要性已得到证实，但在黑色素瘤中的知识仍然有限。这篇综述检查了在黑色素瘤环境中 CCND1 基因和细胞周期蛋白 D1 蛋白上调的发表数据，重点关注基因激活所涉及的途径和分子机制，以及临床和治疗意义。
