广泛使用的药品和个人护理产品化合物的微生物转化
Microbial transformation of widely used pharmaceutical and personal care product compounds.
作者信息
Porter Abigail W, Wolfson Sarah J, Häggblom Max, Young Lily Y
机构信息
Department of Environmental Sciences, School of Environmental and Biological Sciences, Rutgers, the State University of New Jersey, New Brunswick, NJ, USA.
Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
出版信息
F1000Res. 2020 Feb 21;9. doi: 10.12688/f1000research.21827.1. eCollection 2020.
Abstract
Pharmaceutical and personal care products (PPCPs) are commonly used chemicals that are increasingly detected in urban-impacted environments, particularly those receiving treated wastewater. PPCPs may have toxicological effects on the macrofauna that are exposed through contaminated water; thus, there is interest in microbially mediated transformations that may degrade PPCPs. This review discusses specific examples of PPCP transformations that may occur in anoxic environments, including O-methylation and O-demethylation.
摘要
药品和个人护理产品（PPCPs）是常用化学品，在受城市影响的环境中，尤其是那些接收经处理废水的环境中，其检出率日益增加。PPCPs可能会对通过受污染水体接触到的大型动物产生毒理学影响；因此，人们对可能降解PPCPs的微生物介导转化过程很感兴趣。本综述讨论了可能在缺氧环境中发生的PPCP转化的具体例子，包括O-甲基化和O-去甲基化。
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