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一种新型乳酸发酵大蒜提取物功能性食品对急性肝损伤的保肝作用。

Hepatoprotective effect of a novel lactic acid-fermented garlic extract functional food product against acute liver injury.

作者信息

Kim Tae Min, Kim Ki Hoon, Jo Jeong Hyun, Park Joonghoon, Kwon Yong Sam, Yang Je Hoon

机构信息

Graduate School of International Agricultural Technology Seoul National University Pyeongchang Korea.

Institutes of Green-Bio Science and Technology Seoul National University Pyeongchang Korea.

出版信息

Food Sci Nutr. 2020 Jan 5;8(2):1012-1019. doi: 10.1002/fsn3.1385. eCollection 2020 Feb.

DOI:10.1002/fsn3.1385
PMID:32148809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7020270/
Abstract

Lactic acid-fermented garlic extract (LAFGE) has been shown to have hepatoprotective role in liver diseases. This study was conducted to evaluate the efficacy of a new LAFGE-based hepatoprotective functional food product (named D-18-007) formulated with other additive components, including l-arginine, l-ornithine, and the leaf extract of licorice and artichoke. In a rat model of d-galactosamine(GalN)/LPS-induced liver injury, the survival was significantly higher in animals treated with D-18-007 than in animals treated with LAFGE. The hepatic injury was alleviated by either LAFGE or D-18-007, but the overall effect was more significant in D-18-007, as shown by the necrosis, histology, and serum analyses. Also, the decrease in GalN/LPS-induced lipid peroxidation in the liver tissue was more significant in D-18-007 than LAFGE. The decrease in IL-6 protein in the liver was similar between LAFGE and D-18-007. Moreover, we compared the amount of the bile in normal animals and found that D-18-007 has better choleretic activity than LAFGE. Using this acute liver injury model, our results suggest that D-18-007 has an enhanced hepatoprotective effect in acute liver injury compared with LAFGE alone.

摘要

乳酸发酵大蒜提取物（LAFGE）已被证明在肝脏疾病中具有肝脏保护作用。本研究旨在评估一种新的基于LAFGE的肝脏保护功能性食品（名为D - 18 - 007）的功效，该产品由其他添加剂成分配制而成，包括L - 精氨酸、L - 鸟氨酸以及甘草和朝鲜蓟的叶提取物。在D - 半乳糖胺（GalN）/脂多糖（LPS）诱导的肝损伤大鼠模型中，用D - 18 - 007治疗的动物存活率显著高于用LAFGE治疗的动物。LAFGE或D - 18 - 007均可减轻肝损伤，但从坏死、组织学和血清分析来看，总体效果在D - 18 - 007中更为显著。此外，D - 18 - 007使肝脏组织中GalN/LPS诱导的脂质过氧化降低的程度比LAFGE更显著。LAFGE和D - 18 - 007使肝脏中白细胞介素 - 6蛋白降低的程度相似。此外，我们比较了正常动物的胆汁量，发现D - 18 - 007比LAFGE具有更好的利胆活性。利用这种急性肝损伤模型，我们的结果表明，与单独使用LAFGE相比，D - 18 - 007在急性肝损伤中具有更强的肝脏保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af7e/7020270/8db3cb40ac48/FSN3-8-1012-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af7e/7020270/903730996205/FSN3-8-1012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af7e/7020270/6f3032e38294/FSN3-8-1012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af7e/7020270/b1aaeb57bc0a/FSN3-8-1012-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af7e/7020270/df3a463cb80f/FSN3-8-1012-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af7e/7020270/8db3cb40ac48/FSN3-8-1012-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af7e/7020270/903730996205/FSN3-8-1012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af7e/7020270/6f3032e38294/FSN3-8-1012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af7e/7020270/b1aaeb57bc0a/FSN3-8-1012-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af7e/7020270/df3a463cb80f/FSN3-8-1012-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af7e/7020270/8db3cb40ac48/FSN3-8-1012-g005.jpg

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