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某基因中的单核苷酸多态性与中国人群噪声性听力损失相关。 （原文中“in”后面缺少具体基因名称，此译文根据常见情况补充了“某基因”，以便使句子完整通顺）

Single-Nucleotide Polymorphisms in are Associated with Noise-Induced Hearing Loss in a Chinese Population.

作者信息

Wang Ning, Wang Boshen, Guo Jiadi, Zhang Suhao, Han Lei, Zhang Juan, Zhu Baoli

机构信息

Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China.

Jiangsu ProvincialCenter for Disease Prevention and Control, Nanjing 210009, Jiangsu, China.

出版信息

Biochem Res Int. 2020 Feb 17;2020:9589310. doi: 10.1155/2020/9589310. eCollection 2020.

DOI:10.1155/2020/9589310
PMID:32148964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7048908/
Abstract

OBJECTIVES

The purpose of this study was to investigate the correlation between single-nucleotide polymorphism (SNP) in 3'UTR of gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.

METHODS

We conducted a case-control study involving 1040 cases and 1060 controls. The effects of SNPs on gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.

RESULTS

We genotyped four SNPs (rs2257082, rs11077, rs7755135, and rs1106841) in the gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on . The genetic polymorphism, rs11077, within is associated with the risk of noise-induced hearing loss in a Chinese population. gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.

摘要

目的

本研究旨在探讨基因3'非翻译区单核苷酸多态性（SNP）与噪声性听力损失（NIHL）发生之间的相关性，并进一步探究NIHL中微小RNA（miRNA）对基因及NIHL发生的调控机制。

方法

我们进行了一项病例对照研究，涉及1040例病例和1060例对照。研究SNP对基因及噪声性听力损失（NIHL）发生的影响，并进一步探究NIHL中miRNA的调控机制。

结果

我们对基因中的四个SNP（rs2257082、rs11077、rs7755135和rs1106841）进行基因分型，研究其与噪声性听力损失（NIHL）发生之间的关系，并进一步探究NIHL中miRNA对基因及噪声性听力损失（NIHL）发生的调控机制，以及NIHL中miRNA对基因及噪声性听力损失（NIHL）发生的调控机制，还进一步探究NIHL中miRNA对……的调控机制。基因内的遗传多态性rs11077与中国人群噪声性听力损失风险相关。研究基因及噪声性听力损失（NIHL）发生，并进一步探究NIHL中miRNA的调控机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6a/7048908/8ffd724ea66a/BRI2020-9589310.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6a/7048908/26952a1c3c9d/BRI2020-9589310.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6a/7048908/ea8811aaffac/BRI2020-9589310.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6a/7048908/2a79be060c2b/BRI2020-9589310.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6a/7048908/8ffd724ea66a/BRI2020-9589310.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6a/7048908/26952a1c3c9d/BRI2020-9589310.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6a/7048908/ea8811aaffac/BRI2020-9589310.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6a/7048908/2a79be060c2b/BRI2020-9589310.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6a/7048908/8ffd724ea66a/BRI2020-9589310.004.jpg

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