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本文引用的文献

1
Clinical Practice Guidelines for Management of Schizophrenia.精神分裂症管理临床实践指南
Indian J Psychiatry. 2017 Jan;59(Suppl 1):S19-S33. doi: 10.4103/0019-5545.196972.
2
Intramuscular olanzapine versus intramuscular haloperidol plus lorazepam for the treatment of acute schizophrenia with agitation: An open-label, randomized controlled trial.肌内注射奥氮平与肌内注射氟哌啶醇加劳拉西泮治疗急性激越性精神分裂症:一项开放标签随机对照试验。
J Formos Med Assoc. 2015 May;114(5):438-45. doi: 10.1016/j.jfma.2015.01.018. Epub 2015 Mar 17.
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Tardive dyskinesia (syndrome): Current concept and modern approaches to its management.迟发性运动障碍(综合征):当前概念和现代管理方法。
Psychiatry Clin Neurosci. 2015 Jun;69(6):321-34. doi: 10.1111/pcn.12270. Epub 2015 Feb 9.
4
New roles for pharmacists in community mental health care: a narrative review.药剂师在社区精神卫生保健中的新角色:一项叙述性综述。
Int J Environ Res Public Health. 2014 Oct 21;11(10):10967-90. doi: 10.3390/ijerph111010967.
5
Management of psychosis and schizophrenia in adults: summary of updated NICE guidance.成人精神病和精神分裂症的管理:NICE最新指南总结
BMJ. 2014 Feb 12;348:g1173. doi: 10.1136/bmj.g1173.
6
A comprehensive review of the impact of clinical pharmacy services on patient outcomes in mental health.临床药学服务对精神健康患者结局影响的综合评价。
Int J Clin Pharm. 2014 Apr;36(2):222-32. doi: 10.1007/s11096-013-9900-y. Epub 2013 Dec 4.
7
Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology.英国精神药理学协会发布的抗精神分裂症药物治疗的循证指南:推荐意见。
J Psychopharmacol. 2011 May;25(5):567-620. doi: 10.1177/0269881110391123. Epub 2011 Feb 3.
8
[Management of the violent or agitated patient].[暴力或躁动患者的管理]
Braz J Psychiatry. 2010 Oct;32 Suppl 2:S96-103. doi: 10.1590/s1516-44462010000600006.
9
Adverse effects of antipsychotic medications.抗精神病药物的不良反应。
Am Fam Physician. 2010 Mar 1;81(5):617-22.
10
The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements.2009 年精神分裂症 PORT 精神药理学治疗建议和总结陈述。
Schizophr Bull. 2010 Jan;36(1):71-93. doi: 10.1093/schbul/sbp116. Epub 2009 Dec 2.

一例无药物滥用史的青年男性精神分裂症病例:临床药师干预对患者预后的影响

A Case of Schizophrenia in a Young Male Adult with no History of Substance Abuse: Impact of Clinical Pharmacists' Interventions on Patient Outcome.

作者信息

Opare-Addo Mercy N A, Mensah Josephine, Aboagye Grace Owusu

机构信息

Department of Pharmacy Practice, Kwame Nkrumah University of Science and Technology (KNUST), PMB, U.P.O., Kumasi, Ghana.

Department of Surgery, Pharmacy Unit, Korle Bu Teaching Hospital, P.O. Box 77, Accra, Ghana.

出版信息

Case Rep Psychiatry. 2020 Feb 15;2020:3419609. doi: 10.1155/2020/3419609. eCollection 2020.

DOI:10.1155/2020/3419609
PMID:32148991
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7044485/
Abstract

Schizophrenia is a chronic and severe mental disorder characterized by distortions in thinking, perception, emotions, language, sense of self, and behaviour. This report presents the role of clinical pharmacists in the management of a patient diagnosed with schizophrenia with symptoms of paranoia. A gainfully employed young African male adult reported to be roaming around town moving from one bank to another was arrested. The patient was referred to the psychiatric unit of a hospital and diagnosed with schizophrenia. Key interventions offered included rapid tranquilization, electroconvulsive therapy, and psychotherapy. Medications administered to the patient while on admission included IV diazepam, IM haloperidol, IV Ketamine, IM flupentixol, olanzapine tablets, and trihexyphenidyl tablets. Issues raised by clinical pharmacists during the patient's admission included need for alternative medication for rapid tranquilization, need for initial investigations and documentation of the patient's vitals, initiation of antipsychotic therapy without initial monitoring and screening for substance abuse, inappropriate dose at initiation of antipsychotic medications, untreated indication, and incidence of missed doses. Interventions by the clinical pharmacists contributed to improvement in the patient's symptoms prior to hospital discharge. The case proves that it is critical for clinical pharmacists to be involved in the multidisciplinary team during management of patients with psychosis.

摘要

精神分裂症是一种慢性严重精神障碍,其特征是思维、感知、情绪、语言、自我意识和行为出现扭曲。本报告介绍了临床药师在管理一名被诊断为患有伴有妄想症状的精神分裂症患者中的作用。一名有工作的年轻非洲成年男性,据报道在镇上四处游荡,从一家银行转到另一家银行,随后被逮捕。该患者被转至一家医院的精神科病房,并被诊断为精神分裂症。提供的关键干预措施包括快速镇静、电休克治疗和心理治疗。患者住院期间使用的药物包括静脉注射地西泮、肌肉注射氟哌啶醇、静脉注射氯胺酮、肌肉注射三氟噻吨、奥氮平片和苯海索片。临床药师在患者住院期间提出的问题包括需要替代快速镇静药物、需要对患者生命体征进行初步检查和记录、在未对药物滥用进行初始监测和筛查的情况下启动抗精神病治疗、抗精神病药物起始剂量不当、未治疗的指征以及漏服药物的发生率。临床药师的干预有助于患者在出院前症状得到改善。该病例证明,在精神病患者的管理过程中,临床药师参与多学科团队至关重要。