DMBA 诱导的叙利亚仓鼠口腔癌：地塞米松共同暴露增加致癌作用。
DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition.
机构信息
Department of Pharmacy, Sciences Faculty, Universidad Nacional de Colombia, Bogotá 111321, Colombia.
Corporación Patología Veterinaria (CORPAVET), Bogotá 111321, Colombia.
出版信息
Biomed Res Int. 2020 Feb 13;2020:1470868. doi: 10.1155/2020/1470868. eCollection 2020.
OBJECTIVES
To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis. . Two different experiments were performed. In the first experiment, hamsters' right buccal pouches in group A ( = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B ( = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B (.
RESULTS
The time of macroscopic neoplasm development was reduced when DM-DMBA coexposition was employed, finding tumors after 10-12 weeks of exposition. In addition, the frequency of histopathological lesions was higher.
CONCLUSION
Immunomodulatory action of dexamethasone may reduce the time of oral squamous cell carcinoma (OSCC) induction and may increase the incidence of neoplasms developed.
目的
研究在诱导仓鼠颊囊 DMBA 致癌过程中全身性给予免疫抑制剂地塞米松（DM）的效果。进行了两项不同的实验。在第一项实验中，第 A 组（n=10）的右侧颊囊每周涂三次 7,12-二甲基苯并蒽（DMBA）0.5%，而第 B 组（n=10）的颊囊每周涂三次 7,12-二甲基苯并蒽（DMBA）0.5%。
结果
当采用 DM-DMBA 共暴露时，宏观肿瘤发展的时间缩短，在暴露 10-12 周后发现肿瘤。此外，组织病理学病变的频率更高。
结论
地塞米松的免疫调节作用可能会减少口腔鳞状细胞癌（OSCC）诱导的时间，并可能增加所形成的肿瘤的发生率。
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