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Optimization of IRAK1/4/pan-FLT3 kinase inhibitors as treatments for acute myeloid leukemia.
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Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1.
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Discovery of IRAK1/4/pan-FLT3 Kinase Inhibitors as Treatments for Acute Myeloid Leukemia.
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Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML.
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Targeted Therapies in Cancer: To Be or Not to Be, Selective.
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本文引用的文献

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Overcoming adaptive therapy resistance in AML by targeting immune response pathways.
Sci Transl Med. 2019 Sep 4;11(508). doi: 10.1126/scitranslmed.aaw8828.
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Quizartinib tested in patients with high-risk AML.
Nat Rev Clin Oncol. 2018 Sep;15(9):532. doi: 10.1038/s41571-018-0061-8.
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FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions.
Mol Cancer Ther. 2017 Jun;16(6):991-1001. doi: 10.1158/1535-7163.MCT-16-0876.
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Midostaurin approved for FLT3-mutated AML.
Blood. 2017 Jun 29;129(26):3403-3406. doi: 10.1182/blood-2017-05-782292. Epub 2017 May 25.
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Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia.
Invest New Drugs. 2017 Oct;35(5):556-565. doi: 10.1007/s10637-017-0470-z. Epub 2017 May 17.
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Heterogeneous resistance to quizartinib in acute myeloid leukemia revealed by single-cell analysis.
Blood. 2017 Jul 6;130(1):48-58. doi: 10.1182/blood-2016-04-711820. Epub 2017 May 10.
8
Preclinical studies of gilteritinib, a next-generation FLT3 inhibitor.
Blood. 2017 Jan 12;129(2):257-260. doi: 10.1182/blood-2016-10-745133. Epub 2016 Dec 1.
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How I treat FLT3-mutated AML.
Blood. 2017 Feb 2;129(5):565-571. doi: 10.1182/blood-2016-09-693648. Epub 2016 Nov 21.
10
FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors.
Leukemia. 2015 Dec;29(12):2390-2. doi: 10.1038/leu.2015.165. Epub 2015 Jun 25.

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