Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
IUBMB Life. 2020 Jul;72(7):1271-1285. doi: 10.1002/iub.2266. Epub 2020 Mar 9.
Biofilms are microbial communities established in the self-produced extracellular substances that include up to 80% of associated microbial infections. During biofilm formation, bacterial cells shift from the planktonic forms to aggregated forms surrounded by an extracellular polymeric substance. The bacterial biofilm shows resistance against immune reactions as well as antibiotics and is potentially able to cause disorders by both device-related and nondevice-related infections. The nondevice-related bacterial biofilm infections include dental plaque, urinary tract infections, cystic fibrosis, otitis media, infective endocarditis, tonsillitis, periodontitis, necrotizing fasciitis, osteomyelitis, infectious kidney stones, and chronic inflammatory diseases. In this review, we will summarize and examine the literature about bacterial biofilm infections unrelated to indwelling devices.
生物膜是在自身产生的细胞外物质中建立的微生物群落，其中包括多达 80%的相关微生物感染。在生物膜形成过程中，细菌细胞从浮游形式转变为被细胞外聚合物物质包围的聚集形式。细菌生物膜对免疫反应以及抗生素具有抵抗力，并且有可能通过与器械相关和非器械相关的感染引起疾病。非器械相关的细菌生物膜感染包括牙菌斑、尿路感染、囊性纤维化、中耳炎、感染性心内膜炎、扁桃体炎、牙周炎、坏死性筋膜炎、骨髓炎、感染性肾结石和慢性炎症性疾病。在这篇综述中，我们将总结和检查与留置装置无关的细菌生物膜感染的文献。
