National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, P. R. China.
Science and Education Department, Beijing Physical Examination Center, Beijing, P. R. China.
PLoS One. 2020 Mar 9;15(3):e0228312. doi: 10.1371/journal.pone.0228312. eCollection 2020.
The performance of VereMTBTM Detection Kit for detection of multidrug-resistant tuberculosis (MDR-TB) was validated by using 124 sputum samples. Comparing with MGIT culture, the sensitivity and specificity of VereMTB Detection Kit for MTBC detection were 97.0% and 98.3%, respectively. Compared with MGIT DST, the sensitivity and specificity of VereMTB Detection Kit for RIF resistance detection were 85.7% and 93.9%, respectively, and the sensitivity and specificity of VereMTB Detection Kit for INH resistance detection were 75.0% and 95.7%, respectively. 6 NTM samples were also detected and identified correctly. The VereMTB Detection Kit can detect MDR-TB rapidly and accurately in sputum samples from TB suspects.
VereMTB Detection Kit 对 124 份痰样本进行了检测，验证了其对耐多药结核病（MDR-TB）的检测性能。与 MGIT 培养相比，VereMTB Detection Kit 对 MTBC 的检测灵敏度和特异性分别为 97.0%和 98.3%。与 MGIT DST 相比，VereMTB Detection Kit 对利福平耐药性检测的灵敏度和特异性分别为 85.7%和 93.9%，对异烟肼耐药性检测的灵敏度和特异性分别为 75.0%和 95.7%。6 份非结核分枝杆菌样本也被正确检测和鉴定。VereMTB Detection Kit 可快速准确地检测疑似结核病患者痰样本中的 MDR-TB。
