Laboratoire Angevin de Recherche en Ingénierie des Systèmes, EA7315, University of Angers - Université Angers, Angers, France.
Department of Physical and Rehabilitation Medicine, Angers University Hospital, Angers, France.
Ann Clin Transl Neurol. 2020 Apr;7(4):554-558. doi: 10.1002/acn3.50997. Epub 2020 Mar 9.
Vitamin D is involved in brain health and function. Our objective was to determine whether lower 25-hydroxyvitamin D (25OHD) concentration was associated with focal brain volume reduction in older adults. Serum 25OHD concentration was measured among 53 older adults (72 ± 5 years; 38% female; mean 25OHD = 67.3 ± 20.8 nmol/L). Gray matter volume (GMV) was automatically segmented using voxel-based morphometry with CAT12 software. Covariables were age, gender, education, total intracranial volume, and season. Serum 25OHD was positively associated with GMV in left calcarine sulcus (P < 0.05, TFCE, FWE-corrected). We found atrophy of the calcarine sulcus with lower 25OHD concentrations in older adults.
维生素 D 与大脑健康和功能有关。我们的目的是确定老年人血清 25-羟维生素 D（25OHD）浓度较低是否与局部脑容量减少有关。在 53 名老年人（72±5 岁；38%为女性；平均 25OHD 为 67.3±20.8nmol/L）中测量血清 25OHD 浓度。使用 CAT12 软件进行基于体素的形态计量学自动分割灰质体积（GMV）。协变量为年龄、性别、教育程度、总颅内体积和季节。血清 25OHD 与左侧距状沟 GMV 呈正相关（P<0.05，TFCE，FWE 校正）。我们发现老年人的 25OHD 浓度较低，距状沟出现萎缩。
