Annweiler Cédric, Bartha Robert, Karras Spyridon N, Gautier Jennifer, Roche Frédéric, Beauchet Olivier
Department of Geriatric Medicine, Angers University Hospital; UPRES EA4638, University of Angers, UNAM, France; Research Center on Autonomy and Longevity (CeRAL), Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON, Canada.
Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON, Canada.
Exp Gerontol. 2015 Mar;63:41-7. doi: 10.1016/j.exger.2015.01.049. Epub 2015 Jan 30.
Vitamin D insufficiency is associated with brain changes. Our objective was to investigate whether vitamin D insufficiency was associated with a greater volume in mm(3) of white matter abnormalities (WMA) in older adults.
Seventy-five Caucasian older community-dwellers (mean, 70.9 ± 5.0 years; 48%female) received a blood test and brain MRI. The volumes of total white matter (WM) and WMA were measured from T1-weighted MR images using automatic, accurate and reproducible segmentation of the brain provided by FreeSurfer. Vitamin D insufficiency was defined a priori as serum 25-hydroxyvitamin D<50 nmol/L. Age, gender, body mass index, mean arterial pressure, use of anti-vascular drugs, education level, Mini-Mental State Examination score, Instrumental Activities of Daily Living score, serum calcium concentration, estimated glomerular filtration rate, and season of evaluation were used as potential confounders.
Participants with vitamin D insufficiency (n = 29) had a greater volume of WMA than the others (4233 ± 4359 mm(3) versus 2658 ± 1544 mm(3), P = 0.028), even after normalization for WM volume (P = 0.031). Vitamin D insufficiency was cross-sectionally associated with an increased ratio of WMA volume to WM volume (fully adjusted β = 0.35, P = 0.047).
Vitamin D insufficiency was associated with increased WMA volume in the studied sample of older adults. These findings may provide insight into the pathophysiology of cognitive and mobility declines in older adults with vitamin D insufficiency.
维生素D缺乏与脑部变化有关。我们的目的是调查老年人维生素D缺乏是否与更大体积（以立方毫米计）的白质异常（WMA）相关。
75名高加索老年社区居民（平均年龄70.9±5.0岁；48%为女性）接受了血液检测和脑部磁共振成像（MRI）检查。使用FreeSurfer提供的自动、准确且可重复的脑部分割方法，从T1加权磁共振图像中测量总白质（WM）和WMA的体积。维生素D缺乏预先定义为血清25-羟基维生素D<50 nmol/L。年龄、性别、体重指数、平均动脉压、抗血管药物使用情况、教育水平、简易精神状态检查表评分、日常生活活动能力量表评分、血清钙浓度、估计肾小球滤过率以及评估季节被用作潜在混杂因素。
维生素D缺乏的参与者（n = 29）的WMA体积比其他人更大（4233±4359立方毫米对2658±1544立方毫米，P = 0.028），即使在对WM体积进行标准化后也是如此（P = 0.031）。维生素D缺乏与WMA体积与WM体积之比增加呈横断面相关（完全调整后β = 0.35，P = 0.047）。
在所研究的老年样本中，维生素D缺乏与WMA体积增加有关。这些发现可能有助于深入了解维生素D缺乏的老年人认知和活动能力下降的病理生理学机制。
