Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo SP 04023-062, Brazil.
Disciplina de Nefrologia, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo SP 04023-062, Brazil.
Int J Mol Sci. 2020 Mar 5;21(5):1782. doi: 10.3390/ijms21051782.
Despite the advancements in cancer treatments, gastric cancer is still one of the leading causes of death worldwide. In this context, it is of great interest to discover new and more effective ways of treating this disease. Accumulated evidences have demonstrated the amplification of 8q24.21 region in gastric tumors. Furthermore, this is the region where the widely known oncogene and different microRNAs are located. MYC deregulation is key in tumorigenesis in various types of tissues, once it is associated with cell proliferation, survival, and drug resistance. microRNAs are a class of noncoding RNAs that negatively regulate the protein translation, and which deregulation is related with gastric cancer development. However, little is understood about the interactions between microRNAs and MYC. Here, we overview the MYC role and its relationship with the microRNAs network in gastric cancer aiming to identify potential targets useful to be used in clinic, not only as biomarkers, but also as molecules for development of promising therapies.
尽管癌症治疗取得了进展，但胃癌仍然是全球主要的死亡原因之一。在这种情况下，发现治疗这种疾病的新方法和更有效的方法非常重要。大量证据表明，胃癌肿瘤中 8q24.21 区域的扩增。此外，这是广泛存在的 癌基因和不同 microRNAs 的位置。MYC 失调是各种组织肿瘤发生的关键，因为它与细胞增殖、存活和耐药性有关。microRNAs 是一类非编码 RNA，可负调控蛋白质翻译，其失调与胃癌的发生有关。然而，人们对 microRNAs 和 MYC 之间的相互作用知之甚少。在这里，我们综述了 MYC 的作用及其与胃癌 microRNAs 网络的关系，旨在确定潜在的临床有用靶点，不仅作为生物标志物，而且作为开发有前途的治疗方法的分子。
Zotero 插件