Xu Xiaomin, Liu Yang, Fu Wenbo, Yao Mingyu, Ding Zhen, Xuan Jiaming, Li Dongxiang, Wang Shengjie, Xia Yongqing, Cao Meiwen
State Key Laboratory of Heavy Oil Processing and Centre for Bioengineering and Biotechnology, University of Petroleum (East China), Qingdao 266580, China.
Heze Key Laboratory of Water Pollution Treatment, Heze Vocational College, Heze 274000, China.
Polymers (Basel). 2020 Mar 5;12(3):580. doi: 10.3390/polym12030580.
Poly(N-isopropylacrylamide) (PNIPAM)-based thermosensitive hydrogels demonstrate great potential in biomedical applications. However, they have inherent drawbacks such as low mechanical strength, limited drug loading capacity and low biodegradability. Formulating PNIPAM with other functional components to form composited hydrogels is an effective strategy to make up for these deficiencies, which can greatly benefit their practical applications. This review seeks to provide a comprehensive observation about the PNIPAM-based composite hydrogels for biomedical applications so as to guide related research. It covers the general principles from the materials choice to the hybridization strategies as well as the performance improvement by focusing on several application areas including drug delivery, tissue engineering and wound dressing. The most effective strategies include incorporation of functional inorganic nanoparticles or self-assembled structures to give composite hydrogels and linking PNIPAM with other polymer blocks of unique properties to produce copolymeric hydrogels, which can improve the properties of the hydrogels by enhancing the mechanical strength, giving higher biocompatibility and biodegradability, introducing multi-stimuli responsibility, enabling higher drug loading capacity as well as controlled release. These aspects will be of great help for promoting the development of PNIPAM-based composite materials for biomedical applications.
基于聚（N-异丙基丙烯酰胺）（PNIPAM）的热敏水凝胶在生物医学应用中显示出巨大潜力。然而，它们存在固有缺点，如机械强度低、药物负载能力有限和生物降解性低。将PNIPAM与其他功能成分混合以形成复合水凝胶是弥补这些不足的有效策略，这对它们的实际应用大有裨益。本综述旨在对用于生物医学应用的基于PNIPAM的复合水凝胶进行全面观察，以指导相关研究。它涵盖了从材料选择到杂化策略的一般原则，以及通过关注包括药物递送、组织工程和伤口敷料在内的几个应用领域来提高性能。最有效的策略包括加入功能性无机纳米颗粒或自组装结构以形成复合水凝胶，以及将PNIPAM与其他具有独特性能的聚合物嵌段连接以制备共聚水凝胶，这可以通过提高机械强度、赋予更高的生物相容性和生物降解性、引入多刺激响应性、实现更高的药物负载能力以及控释来改善水凝胶的性能。这些方面将对促进用于生物医学应用的基于PNIPAM的复合材料的发展有很大帮助。
