Zhao Dan, Ma Wenting, Wang Rong, Yang Xinzhou, Li Jun, Qiu Ting, Xiao Xincai
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, Wuhan 430074, China.
Polymers (Basel). 2019 Jul 11;11(7):1171. doi: 10.3390/polym11071171.
Fluorescence/temperature-sensitive hydrogels, thanks to their properties in fluorescence and temperature sensitivity, have shown a promising outlook in the fields of drug delivery, cell imaging, etc., and thus become the focus of present research. This paper reports the preparation of green-fluorescence/temperature-sensitive hydrogels through one-step radical polymerization with green fluorescence-emissioned carbon dots as fluorescence probes and N-isopropylacrylamide as a monomer. UV-vis spectra, fluorescence spectra, and fluorescence microscope imaging have been used to characterize the prepared hydrogel, and to study their optical and temperature-sensitive properties. It was discovered that the emission of prepared hydrogel is excitation wavelength-dependent, pH responding, and excellent temperature-sensitive, as well as having good biocompatibility. The prepared hydrogel can also be applied as fluorescence ink in the fields of anti-counterfeit identification and appraisal.
荧光/温度敏感水凝胶因其荧光和温度敏感特性，在药物递送、细胞成像等领域展现出广阔前景，从而成为当前研究的焦点。本文报道了以绿色荧光发射碳点为荧光探针、N-异丙基丙烯酰胺为单体，通过一步自由基聚合制备绿色荧光/温度敏感水凝胶的方法。利用紫外可见光谱、荧光光谱和荧光显微镜成像对制备的水凝胶进行表征，并研究其光学和温度敏感特性。发现制备的水凝胶的发射具有激发波长依赖性、pH响应性和优异的温度敏感性，并且具有良好的生物相容性。制备的水凝胶还可作为荧光墨水应用于防伪识别和鉴定领域。
