Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 106, Taiwan.
Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 106, Taiwan; Advanced Membrane Materials Research Center, National Taiwan University of Science and Technology, Taipei 106, Taiwan.
Int J Biol Macromol. 2019 Jul 15;133:545-563. doi: 10.1016/j.ijbiomac.2019.04.131. Epub 2019 Apr 18.
Injectable thermo-responsive hydrogels have been studied for various biomedical applications including; drug delivery, cell encapsulation, and tissue repairing. There are various natural and synthetic polymers which exhibit homogenous injectable solution at ambient temperature and form a gel in human body temperature. Polysaccharide, polypeptide and other biological macromolecule based hydrogels have been getting immense attention in biomedical application due to their low immunogenicity, abundance in nature, high biocompatibility and biodegradability. This manuscript focuses on polysaccharide and polypeptide based thermo-sensitive hydrogels, and some synthetic polymers which forms in situ gel in response to temperature change from ambient to body temperature. The value of numerous reactive functional groups of biological macromolecular polymers has been discussed for effortless modification and design of bio-macromolecule based thermo-sensitive hydrogels. In addition, we emphasized on the basic mechanisms of the thermo-response processes, the strategies to optimize the desired properties and their applications in local delivery approach.
可注射的温敏水凝胶已被研究用于各种生物医学应用，包括药物输送、细胞封装和组织修复。有各种天然和合成聚合物，它们在环境温度下表现出均匀的可注射溶液，并在人体温度下形成凝胶。基于多糖、多肽和其他生物大分子的水凝胶由于其低免疫原性、丰富的天然来源、高生物相容性和可生物降解性，在生物医学应用中受到了极大的关注。本文主要关注多糖和多肽基温敏水凝胶，以及一些在环境温度到体温变化时形成原位凝胶的合成聚合物。讨论了生物大分子聚合物的大量反应性功能基团的价值，以方便地修饰和设计基于生物大分子的温敏水凝胶。此外，我们还强调了温敏过程的基本机制、优化所需特性的策略以及它们在局部递药方法中的应用。
