Miyamoto M, Sugawa H, Mori T, Hashimoto N, Imura H
2nd Division of Internal Medicine, Kyoto University School of Medicine, Japan.
Endocrinol Jpn. 1988 Aug;35(4):607-16. doi: 10.1507/endocrj1954.35.607.
A 47-year-old woman complaining of cold intolerance, general weakness and amenorrhea of 10 months duration was diagnosed, by endocrine examinations, as having panhypopituitarism. Skull x-ray films revealed a slightly enlarged sella with double floor sign and MRI showed a low intensity mass in the pituitary. Transsphenoidal exploration disclosed a degenerated pituitary gland, the histology of which showed a granulomatous lesion with moderate lymphocytic infiltration but containing no multinuclear giant cells. No caseous necrosis, causative microorganisms, or BCG antigen were noted. The present case is considered a variant form of lymphocytic adenohypophysitis.
