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UCSF 小鼠库存数据库应用程序,一个开源的 Web 应用程序,用于在研究社区内共享突变小鼠。

The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community.

机构信息

Department of Obstetrics, Gynecology and Reproductive Science; Center for Reproductive Sciences; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California.

San Francisco, CA 94143.

出版信息

G3 (Bethesda). 2020 May 4;10(5):1503-1510. doi: 10.1534/g3.120.401086.

Abstract

The UCSF Mouse Inventory Database Application is an open-source Web App that provides information about the mutant alleles, transgenes, and inbred strains maintained by investigators at the university and facilitates sharing of these resources within the university community. The Application is designed to promote collaboration, decrease the costs associated with obtaining genetically-modified mice, and increase access to mouse lines that are difficult to obtain. An inventory of the genetically-modified mice on campus and the investigators who maintain them is compiled from records of purchases from external sources, transfers from researchers within and outside the university, and from data provided by users. These data are verified and augmented with relevant information harvested from public databases, and stored in a succinct, searchable database secured on the university network. Here we describe this resource and provide information about how to implement and maintain such a mouse inventory database application at other institutions.

摘要

UCSF 小鼠品系数据库应用程序是一个开源 Web 应用程序,提供了该校研究人员持有的突变等位基因、转基因和近交系的信息,并促进了校内社区内这些资源的共享。该应用程序旨在促进合作,降低获得基因修饰小鼠的成本,并增加获取难以获得的小鼠品系的机会。校园内基因修饰小鼠及其维护者的清单是从外部来源购买记录、校内和校外研究人员的转移以及用户提供的数据中编制而成的。这些数据经过验证,并通过从公共数据库中获取的相关信息进行补充,存储在校园网络上安全的简洁、可搜索的数据库中。在这里,我们将介绍这个资源,并提供有关如何在其他机构实施和维护这种小鼠品系数据库应用程序的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4a0/7202022/209648b65afa/1503f1.jpg

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