骨髓间充质干细胞治疗 Wistar 大鼠椎间盘退变。

Treatment of Intervertebral Disc Degeneration in Wistar Rats with Mesenchymal Stem Cells.

机构信息

Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

出版信息

Bull Exp Biol Med. 2020 Feb;168(4):578-582. doi: 10.1007/s10517-020-04756-2. Epub 2020 Mar 9.

DOI:10.1007/s10517-020-04756-2

PMID:32152846

Abstract

We studied the effect of erythropoietin on functional properties of mesenchymal stem cells under conditions of oxidative stress and their therapeutic potential in the treatment of intervertebral disc degeneration in Wistar rats. It was shown that erythropoietin stimulates proliferation under conditions of oxidative stress. Injection of bone marrow mesenchymal stem cells into the damaged intervertebral disc was followed by an increase in the height of the intervertebral disc and activation of repair processes in the nucleus pulposus. The combination of mesenchymal stem cells with erythropoietin provides the best effect of cell therapy in case of intervertebral disc damage.

摘要

我们研究了促红细胞生成素在氧化应激条件下对间充质干细胞功能特性的影响及其在治疗 Wistar 大鼠椎间盘退行性变中的治疗潜力。结果表明，促红细胞生成素在氧化应激条件下刺激增殖。将骨髓间充质干细胞注射到受损的椎间盘后，可增加椎间盘的高度并激活髓核中的修复过程。间充质干细胞与促红细胞生成素联合使用可在椎间盘损伤的情况下提供最佳的细胞治疗效果。