Pang Xiao-Min, Liang Xiu-Lin, Zhou Xia, Liu Jin-Ping, Zhang Zhao, Zheng Jin-Ou
Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Neurol Sci. 2020 Aug;41(8):2165-2174. doi: 10.1007/s10072-020-04322-8. Epub 2020 Mar 9.
Levetiracetam (LEV) is an antiepileptic drug with a novel pharmacological mechanism. Advances in functional magnetic resonance imaging (fMRI) enable researchers to explore the cognitive effects of antiepileptic drugs on the living brain. This study aimed to explore how the functional connectivity patterns of the cognitive networks changed in association with LEV treatment.
Patients with temporal lobe epilepsy (TLE), including both users and nonusers of LEV, were included in this study along with healthy controls. Core cognitive networks were extracted using an independent component analysis approach. Functional connectivity patterns within and between networks were investigated. The relationships between functional connectivity patterns and clinical characteristics were also examined.
The patterns of intranetwork connectivity in the default mode network (DMN), left executive control network (lECN), and dorsal attention network (DAN) differed among the three groups. The internetwork interactions did not show intergroup differences once corrected for multiple comparisons. No correlation between functional connectivity and clinical characteristics was found in patients with TLE.
Changes in intranetwork connectivity are a key effect of LEV administration.
Alterations in intranetwork connectivity patterns may underlie the cognitive effects of LEV administration; this finding improves our understanding of the neural mechanisms of LEV therapy.
左乙拉西坦（LEV）是一种具有新型药理机制的抗癫痫药物。功能磁共振成像（fMRI）技术的进步使研究人员能够探索抗癫痫药物对活体大脑的认知影响。本研究旨在探讨认知网络的功能连接模式如何随LEV治疗而变化。
本研究纳入了颞叶癫痫（TLE）患者，包括LEV使用者和非使用者，以及健康对照者。使用独立成分分析方法提取核心认知网络。研究了网络内部和网络之间的功能连接模式。还检查了功能连接模式与临床特征之间的关系。
默认模式网络（DMN）、左侧执行控制网络（lECN）和背侧注意网络（DAN）的网络内连接模式在三组之间存在差异。经多重比较校正后，网络间相互作用未显示出组间差异。在TLE患者中未发现功能连接与临床特征之间存在相关性。
网络内连接的变化是LEV给药的关键效应。
网络内连接模式的改变可能是LEV给药产生认知效应的基础；这一发现提高了我们对LEV治疗神经机制的理解。
