Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, No 639 Longmian Avenue, Nanjing, 211198, China.
Department of Pharmaceutics, School of Pharmacy, Shanghai Jiatong University, 800 Dongchuan Road, Shanghai, 200003, China.
AAPS PharmSciTech. 2020 Mar 9;21(3):101. doi: 10.1208/s12249-020-01641-z.
The hydrophobicity of bioactive molecules poses a considerable problem in the pharmaceutical and the food industry. Using food-based protein nanocarriers is one promising way to deliver hydrophobic molecules. These types of protein possess many functional properties such as surface activity, water-binding capacity, emulsification, foaming, gelation, and antioxidant activity, as well as their incorporation in the food industry as ingredients. Besides, they express low toxicity, are less expensive compared to synthetic polymers, and are biodegradable. This review aims to give a brief overview of the recent studies done using food proteins as colloidal delivery systems for hydrophobic and poorly soluble compounds.
疏水性生物活性分子在制药和食品工业中是一个相当大的问题。使用基于食品的蛋白质纳米载体是输送疏水性分子的一种很有前途的方法。这些类型的蛋白质具有许多功能特性，如表面活性、水结合能力、乳化、泡沫形成、凝胶化和抗氧化活性，以及它们作为成分在食品工业中的应用。此外，它们的表达毒性低，与合成聚合物相比成本更低，并且可生物降解。本综述旨在简要概述最近使用食品蛋白作为胶体输送系统用于输送疏水性和难溶性化合物的研究。
