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当前功能性食品的纳米递药系统的发展趋势:系统综述。

Current trends in nano-delivery systems for functional foods: a systematic review.

机构信息

Department of Human Ecology, Delaware State University, Dover, Delaware, United States.

Department of Human Nutrition, St. Francis Xavier University, Antigonish, Nova Scotia, Canada.

出版信息

PeerJ. 2023 Mar 17;11:e14980. doi: 10.7717/peerj.14980. eCollection 2023.

Abstract

BACKGROUND

Increased awareness of the relationship between certain components in food beyond basic nutrition and health has generated interest in the production and consumption. Functional foods owe much of their health benefits to the presence of bioactive components. Despite their importance, their poor stability, solubility, and bioavailability may require the use of different strategies including nano-delivery systems (NDS) to sustain delivery and protection during handling, storage, and ingestion. Moreover, increasing consumer trend for non-animal sourced ingredients and interest in sustainable production invigorate the need to evaluate the utility of plant-based NDS.

METHOD

In the present study, 129 articles were selected after screening from Google Scholar searches using key terms from current literature.

SCOPE

This review provides an overview of current trends in the use of bioactive compounds as health-promoting ingredients in functional foods and the main methods used to stabilize these components. The use of plant proteins as carriers in NDS for bioactive compounds and the merits and challenges of this approach are also explored. Finally, the review discusses the application of protein-based NDS in food product development and highlights challenges and opportunities for future research.

KEY FINDINGS

Plant-based NDS is gaining recognition in food research and industry for their role in improving the shelf life and bioavailability of bioactives. However, concerns about safety and possible toxicity limit their widespread application. Future research efforts that focus on mitigating or enhancing their safety for food applications is warranted.

摘要

背景

人们越来越意识到食物中某些成分除了基本营养和健康之外,与健康之间的关系,这激发了人们对其生产和消费的兴趣。功能性食品的许多健康益处都归功于生物活性成分的存在。尽管它们很重要,但由于其稳定性差、溶解度低和生物利用度低,可能需要使用不同的策略,包括纳米传递系统(NDS),以维持在处理、储存和摄入过程中的传递和保护。此外,消费者对非动物来源成分的日益增长的需求以及对可持续生产的兴趣,激发了人们评估植物基 NDS 的实用性的需求。

方法

本研究通过使用当前文献中的关键词在 Google Scholar 搜索中进行筛选,共选择了 129 篇文章。

范围

本文综述了目前在功能性食品中使用生物活性化合物作为促进健康的成分的趋势,以及稳定这些成分的主要方法。还探讨了将植物蛋白作为生物活性化合物的 NDS 载体的应用,以及这种方法的优点和挑战。最后,本文讨论了基于蛋白质的 NDS 在食品产品开发中的应用,并强调了未来研究的挑战和机遇。

主要发现

植物基 NDS 因其能够提高生物活性物质的保质期和生物利用度,在食品研究和工业中得到了认可。然而,对其安全性和潜在毒性的担忧限制了其广泛应用。有必要进行未来的研究工作,以减轻或增强其在食品应用中的安全性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c36/10026715/62d4a779045a/peerj-11-14980-g001.jpg

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