Division of Biomedical Engineering, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.
Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.
Med Biol Eng Comput. 2020 May;58(5):1079-1089. doi: 10.1007/s11517-020-02148-2. Epub 2020 Mar 10.
Stress urinary incontinence (SUI) or urine leakage from urethra occurs due to an increase in abdominal pressure resulting from stress like a cough or jumping height. SUI is more frequent among post-menopausal women. In the absence of bladder contraction, vesical pressure exceeds urethral pressure leading to urine leakage. The main aim of this study is to utilize fluid-structure interaction techniques to model bladder and urethra computationally under an external pressure like sneezing. Both models have been developed with linear elastic properties for the bladder wall while the patient model has also been simulated utilizing the Mooney-Rivlin solid model. The results show a good agreement between the clinical data and the predicted values of the computational models, specifically the pressure at the center of the bladder. There is 1.3% difference between the predicted vesical pressure and the vesical pressure obtained from urodynamic tests. It can be concluded that the accuracy of the predicted pressure in the center of the bladder is significantly higher for the simulation assuming nonlinear material property (hyperelastic) for the bladder in comparison to the accuracy of the linear elastic model. The model is beneficial for exploring treatment solutions for SUI disorder. Graphical abstract .
压力性尿失禁（SUI）或尿道漏尿是由于腹部压力增加引起的，这种压力可能是咳嗽或跳跃等引起的。绝经后妇女更容易出现 SUI。在没有膀胱收缩的情况下，膀胱内压超过尿道内压，导致尿液漏出。本研究的主要目的是利用流固耦合技术，在打喷嚏等外部压力下对膀胱和尿道进行计算机建模。这两种模型都采用线性弹性特性来模拟膀胱壁，而患者模型也利用 Mooney-Rivlin 固体模型进行了模拟。结果表明，临床数据与计算模型的预测值之间存在良好的一致性，特别是在膀胱中心的压力。预测的膀胱压力与尿动力测试获得的膀胱压力之间存在 1.3%的差异。可以得出结论，与线性弹性模型相比，假设膀胱的非线性材料特性（超弹性）对膀胱进行模拟时，预测的膀胱中心压力的准确性要高得多。该模型有助于探索治疗压力性尿失禁的方法。
