Li Ming, Yao Xiaoxiao, Sun Lihua, Zhao Lihong, Xu Wenbo, Zhao Haisheng, Zhao Fangyi, Zou Xiaohan, Cheng Ziqian, Li Bingjin, Yang Wei, Cui Ranji
Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, China.
Front Psychol. 2020 Feb 20;11:80. doi: 10.3389/fpsyg.2020.00080. eCollection 2020.
Depression is one of the most common disorders causing mortality around the world. Although electroconvulsive therapy (ECT) is, along with antidepressants and psychotherapy, one of the three major treatments of depression, it is still considered as the last resort for depressed patients. This situation is partially due to limited studies and uncertainty regarding its mechanism. However, decades of increased research have focused on the effects of ECT on depression and its potential mechanism. Furthermore, these investigations may suggest that ECT should be a first-line therapy for depression due to its profound effects in relieving desperation in certain situations. Here, we outline recent clinical and preclinical studies and summarize the advantages and disadvantages of ECT. Thus, this review may provide some hints for clinical application.
抑郁症是全球范围内导致死亡的最常见疾病之一。尽管电休克疗法（ECT）与抗抑郁药和心理治疗一样，是抑郁症的三大主要治疗方法之一，但它仍被视为抑郁症患者的最后手段。这种情况部分是由于关于其机制的研究有限且存在不确定性。然而，数十年来越来越多的研究集中在ECT对抑郁症的影响及其潜在机制上。此外，这些研究可能表明，由于ECT在某些情况下对缓解绝望情绪有显著效果，它应该成为抑郁症的一线治疗方法。在此，我们概述了近期的临床和临床前研究，并总结了ECT的优缺点。因此，本综述可能为临床应用提供一些启示。
