Girlich Delphine, Bonnin Rémy A, Dortet Laurent, Naas Thierry
EA7361 "Structure, dynamic, function and expression of broad spectrum β-lactamases", LabEx Lermit, Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-producing Enterobacteriaceae, Le Kremlin-Bicêtre, France.
Front Microbiol. 2020 Feb 21;11:256. doi: 10.3389/fmicb.2020.00256. eCollection 2020.
spp. are commensal Enterobacterales of the human digestive tract. At the same time, is commonly involved in urinary tract infections (UTI). is naturally resistant to several antibiotics including colistin and shows reduced susceptibility to imipenem. However higher levels of resistance to imipenem commonly occur in isolates consecutively to the loss of porins, reduced expression of penicillin binding proteins (PBPs) PBP1a, PBP2, or acquisition of several antibiotic resistance genes, including carbapenemase genes. In addition, resistance to non-β-lactams is also frequently reported including molecules used for treating UTI infections (e.g., fluoroquinolones, nitrofurans). Emergence and spread of multidrug resistant isolates, including those producing ESBLs, AmpC cephalosporinases and carbapenemases, are being more and more frequently reported. This review covers spp. with a focus on the different genetic mechanisms involved in the acquisition of resistance genes to multiple antibiotic classes turning into a dreadful pandrug resistant bacteria and resulting in difficult to treat infections.
某些种是人类消化道的共生肠杆菌科细菌。同时，它通常涉及尿路感染（UTI）。它对包括黏菌素在内的多种抗生素天然耐药，并且对亚胺培南的敏感性降低。然而，在连续丧失孔蛋白、青霉素结合蛋白（PBPs）PBP1a、PBP2表达降低或获得包括碳青霉烯酶基因在内的多个抗生素耐药基因后，分离株对亚胺培南的耐药水平通常会更高。此外，对非β-内酰胺类药物的耐药性也经常被报道，包括用于治疗UTI感染的分子（如氟喹诺酮类、硝基呋喃类）。越来越频繁地报道了多重耐药分离株的出现和传播，包括那些产生超广谱β-内酰胺酶（ESBLs）、AmpC头孢菌素酶和碳青霉烯酶的分离株。本综述涵盖了某些种，重点关注获得对多种抗生素类别的耐药基因所涉及的不同遗传机制，这些机制使某些种变成可怕的泛耐药细菌，并导致难以治疗的感染。
