Laboratoire de Bactériologie, Centre Hospitalier Universitaire, Besançon, France
UMR6249 CNRS Chrono-Environnement, Université de Bourgogne Franche-Comté, Besançon, France.
Antimicrob Agents Chemother. 2019 May 24;63(6). doi: 10.1128/AAC.00191-19. Print 2019 Jun.
Nineteen isolates producing the carbapenemase OXA-23 were recovered over a 2-year period in 19 French hospitalized patients, of whom 12 had community onset infections. The isolates exhibited a slightly reduced susceptibility to carbapenems. Whole-genome analysis revealed that all 19 isolates formed a cluster compared to 149 other isolates. Because of its susceptibility to carbapenems, this clone may be misidentified as a penicillinase producer while it constitutes a reservoir of the OXA-23-encoding gene in the community.
在 2 年内，19 株产碳青霉烯酶 OXA-23 的分离株从 19 名法国住院患者中分离出来，其中 12 例为社区发病感染。这些分离株对碳青霉烯类药物的敏感性略有降低。全基因组分析显示，与 149 株其他分离株相比，所有 19 株分离株形成了一个聚类。由于对碳青霉烯类药物的敏感性，该克隆可能被错误地鉴定为青霉素酶产生菌，而实际上它构成了社区中 OXA-23 编码基因的库。
