Voinescu Ioana, Petre Alexandru, Burlibasa Mihai, Oancea Luminita
Faculty of Midwifery and Medical Assisting, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Occlusion and Fixed Prosthodontic Department, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Maedica (Bucur). 2019 Dec;14(4):384-390. doi: 10.26574/maedica.2019.14.4.384.
The association between chronic periodontitis and cardiovascular disease is still controversial, despite the plethora of research on this topic. The objective of this systematic review is to update the level of evidence on connection between periodontal and cardiovascular disease. The review question is: could a link between periodontal disease and ischemic cardiac disease be established? A PubMed, Science Direct and Scopus systematic search was performed, which was restricted only to articles published in English or French during the last five years. This study followed PRISMA statement guidelines. A significant relationship between the periodontal and cardiovascular pathology in 17 selected studies was observed, although there was a huge methodological heterogeneity and no randomized study was found. It can be concluded that there is a connection between periodontal and cardiovascular disease, but the link mechanism is still not strongly proved. The scientific evidence level of the future research must be improved.
尽管针对慢性牙周炎与心血管疾病之间的关联已有大量研究，但该关联仍存在争议。本系统评价的目的是更新牙周病与心血管疾病之间联系的证据水平。评价问题为：能否确立牙周病与缺血性心脏病之间的联系？我们在PubMed、Science Direct和Scopus数据库进行了系统检索，仅纳入过去五年以英文或法文发表的文章。本研究遵循PRISMA声明指南。在17项纳入研究中观察到牙周病与心血管病理之间存在显著关联，尽管存在巨大的方法学异质性，且未发现随机对照研究。可以得出结论，牙周病与心血管疾病之间存在联系，但联系机制仍未得到有力证实。未来研究的科学证据水平必须提高。
